| 微生物转化在天然产物研究中的应用 |
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| 引用本文： | 刘庆鑫,李慧梁,柳润辉.微生物转化在天然产物研究中的应用[J].药学实践杂志,2012,30(5):321-325. |
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| 作者姓名： | 刘庆鑫 李慧梁 柳润辉 |
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| 作者单位： | 福建中医药大学药学系;第二军医大学药学院天然药物化学教研室 |
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| 摘 要： | 随着生物科学技术的不断发展,微生物转化逐渐应用于天然产物的研究中。本文简介了微生物转化反应的专一有效、反应条件温和、收率高等特点,对近5年来微生物转化在天然产物研究中的应用进行了综述,重点综述了微生物对蒽醌类、黄酮类、萜类、甾体类、生物碱类和苷类化合物的生物转化,并对其发展前景进行了展望。
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| 关 键 词： | 微生物转化 天然产物研究 应用 |
| 收稿时间： | 2/2/2012 12:00:00 AM |
| 修稿时间： | 2012/3/26 0:00:00 |
Application of microbial transformation in natural products research |
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| LIU Qing-xin,LI Hui-liang and LIU Run-hui.Application of microbial transformation in natural products research[J].The Journal of Pharmaceutical Practice,2012,30(5):321-325. |
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| Authors: | LIU Qing-xin LI Hui-liang and LIU Run-hui |
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| Institution: | 1.Department of Pharmacy,Fujian Traditional Chinese Medicine University,Fuzhou 350108,China;2.Department of Phytochemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) |
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| Abstract: | With the continuous development of biotechnology technology,microbial transformation gradually was applied to the study of natural products.The specific effective reactions,mild reaction conditions and high yield of the microbial transformation were outlined in this paper.The applications were reviewed in the microbial transformation of natural products in recent five years,especially in anthraquinones,flavonoids,terpenoids,steroids,alkaloids and glycosides.The developments of microbial transformation were prospected. |
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| Keywords: | microbial transformation natural products research applications |
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