甲巯咪唑治疗妊娠合并甲状腺功能亢进安全性分析

目的分析甲巯咪唑治疗妊娠合并甲状腺功能亢进的安全性和可行性。方法选择38例妊娠合并甲状腺功能亢进产妇,使用甲巯咪唑治疗,并与未使用药物控制的妊娠合并甲状腺功能亢进产妇进行比较,统计分析甲巯咪唑治疗产妇甲亢后,新生儿甲状腺功能变化以及发生先天性畸形情况。结果在新生儿断脐前抽取脐静脉血检测的甲状腺激素发现,观察组的TT3、TT4、FT3、FT4以及TSH均明显低于对照组（P〈0.05）,观察组新生儿先天性畸形发生率明显少于对照组（P〈0.05）。结论甲巯咪唑治疗妊娠合并甲状腺功能亢进,虽有部分新生儿畸形的发生,但总体上能减少新生儿畸形发生率,维持新生儿甲状腺功能,可在定期监测胎儿生长发育情况的前提下使用。

Safety analysis of Methimazole in the treatment of hyperthyroidism during pregnancy

Objective To analyze the safety and feasibility of Methimazole in the treatment of hyperthyroidism during pregnancy.Methods Thirty-eight puerperae with hyperthyroidism during pregnancy received the Methimazole treatment and were compared with the puerperae with hyperthyroidism during pregnancy who didn’t receive the Methimazole treatment.The neonates’ thyroid function changes and incidence of congenital malformation were analyzed statistically after the Methimazole treatment of hyperthyroidism.Results The thyroid hormone detected in the umbilical cord venous blood extracted before cutting off the umbilical cord showed that the observation group was significantly lower than the control group in the TT3,TT4,FT3,FT4 and TSH(P < 0.05) and that the observation group was significantly lower than the control group in the incidence of congenital malformation(P < 0.05).Conclusion Although the Methimazole treatment of hyperthyroidism during pregnancy leads to some neonatal malformation,but in general it can reduce the incidence of neonatal malformation and maintain neonatal thyroid function,and therefore it can be used in the context of regular monitoring of fetal growth and development.