急性冠状动脉综合征患者血清C反应蛋白、脑钠尿肽、D-二聚体的水平变化及其临床意义

目的探讨血清C反应蛋白（C-reactive protein,CRP）、脑钠尿肽（brain natrium peptide,BNP）和D-二聚体在急性冠状动脉综合征（acute coronary syndrome,ACS）患者中的水平变化及其在ACS发生、发展中的意义。方法选取我院诊断为ACS的患者102例,其中急性心肌梗死（acute myocardial infarction,AMI）患者40例,不稳定型心绞痛患者（unstable angina pectoris,UAP）62例。选取同期住院的稳定型心绞痛（stable angina pectoris,SAP）患者50例,并选取同期健康体检者50例作为对照组。采用免疫透射比浊法测定CRP含量,采用ELISA方法检测BNP含量和D-二聚体含量。并对结果数据进行统计学分析。结果与对照组及SAP组比较,ACS患者CRP、BNP、D-二聚体水平明显升高（P〈0.01）;其中AMI患者上述指标水平明显高于UAP患者（P〈0.01或P〈0.05）。结论 ACS患者血清CRP、BNP、D-二聚体水平明显升高,检测血清CRP、BNP、D-二聚体水平对ACS的辅助诊断、疗效观察及预后判断具有重要价值。

Changes of serum C-reactive protein,brain natriuretic peptide and D-dimer levels in patients with acute coronary ayndrome and their clinical significance

Objective To investigate the changes of serum C-reactive protein(CRP),brain natriuretic peptide(BNP) and D-dimer levels in patients with acute coronary syndrome(ACS) and their clinical significance in the occurrence and development of ACS.Methods 102 patients diagnosed with ACS in our hospital were selected,among whom 40 patients had acute myocardial infarction(AMI) and 62 had unstable angina pectoris(UAP).50 patients with stable angina pectoris(SAP) hospitalized in the corresponding period and 50 healthy people receiving physical examination in the corresponding period were selected as the control group.The CRP levels were measured using the immune turbidimetric test,and the BNP levels and D-dimer levels were determined using the enzyme-linked immuno sorbent assay(ELISA).The result data were statistically analyzed.Results Compared with the control group and the SAP group,the ACS group had significantly elevated CRP,BNP and D-dimer levels(P < 0.01).As for the above indicators,patients with AMI were significantly higher than patients with UAP(P < 0.01 or P < 0.05).Conclusion The CRP,BNP and D-dimer levels significantly elevated in patients with ACS and therefore the detection of CRP,BNP and D-dimer levels was of great value to the aided diagnosis,curative effects observation and prognosis judgment of ACS.