ATP结合盒转运体介导的肝癌多药耐药研究进展

ATP结合盒转运体(ABC转运体)介导的多药耐药(MDR)是肝癌化疗失败的主要原因,研究确定天然的及获得性MDR的产生机制,有利于提出更有效的治疗措施。针对ATP结合盒转运体的肿瘤MDR逆转策略,对于肝癌化疗效果的提高具有重要意义。此外,ATP结合盒转运体可能参与了肿瘤生物学的一些重要过程,发挥药物外排泵以外的作用,为肿瘤的治疗提供了新的研究方向。

Advances in studies on ATP-binding cassette transporter-mediated multidrug resistance in liver cancer

The failure of chemotherapy in liver cancer treatment often occurs as a result of multidrug resistance(MDR) mediated by ATP-binding cassette(ABC) transporters and the development of more effective therapies depends on identifying the mechanisms of intrinsic or acquired MDR.Strategies focused on ABC transporters to overcome MDR have a lot of benefits on the chemotherapy of liver cancer.Furthermore,considerable evidence suggests that the ABC transporters play a fundamental role in tumor biology beyond the efflux of cytotoxic drugs,which indicates a new way of study on cancer therapy.