| 核苷类药物的前药及其研发近况 |
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| 引用本文： | 李文保,董芳华,孙昌俊. 核苷类药物的前药及其研发近况[J]. 药学进展, 2012, 36(7): 300-307 |
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| 作者姓名： | 李文保 董芳华 孙昌俊 |
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| 作者单位： | 1. 济南圣鲁金药物技术开发有限公司,山东济南250101;山东省医学科学院,山东济南250062
2. 济南圣鲁金药物技术开发有限公司,山东济南,250101 |
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| 基金项目： | 国家科技重大专项:重大新药创制项目(No.2010ZX09401-302-2-07,No.2011ZX09102-001-03);泰山学者建设工程专项经费资助项目 |
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| 摘 要： | 核苷类药物被广泛用于治疗各种病毒性疾病和癌症,具有广阔的应用前景。然而,该类药物亦存在口服生物利用度低、代谢过快及毒副作用大等缺点,将其制成前药则有可能解决这些问题。对核苷类药物相关前药的研究进展进行综述,为其进一步研发提供思路。
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| 关 键 词： | 核苷类药物 前药 抗肿瘤药物 抗病毒药物 生物利用度 |
Recent Progress in Research on Prodrugs of Nucleoside Drugs |
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| LI Wen-bao , DONG Fang-hua , SUN Chang-jun. Recent Progress in Research on Prodrugs of Nucleoside Drugs[J]. Progress in Pharmaceutical Sciences, 2012, 36(7): 300-307 |
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| Authors: | LI Wen-bao DONG Fang-hua SUN Chang-jun |
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| Affiliation: | 1(1.Jinan Sanlugen Pharmaceutical Technology Development Co.,Ltd.,Jinan 250101,China;2.Shandong Academy of Medical Sciences,Jinan 250062,China) |
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| Abstract: | Nucleoside drugs have been widely used to treat various viral diseases and cancers.They have a broad application prospect.However,they also have several disadvantages,such as low oral bioavailability,over-quick metabolic rate and serious side effects.The prodrug technique can be applied to solve the above problems.The recent progress in research on related prodrugs of nucleoside drugs was reviewed,so as to provide new ideas for their further development. |
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| Keywords: | nucleoside drug prodrug antitumor drug antiviral drug bioavailability |
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