| 凝血酶蛋白酶激活受体-1作为转移性黑色素瘤治疗潜在靶点的研究进展 |
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| 引用本文： | 周植星,张玥,潘婷婷,徐为人.凝血酶蛋白酶激活受体-1作为转移性黑色素瘤治疗潜在靶点的研究进展[J].药物评价研究,2012(4):276-280. |
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| 作者姓名： | 周植星 张玥 潘婷婷 徐为人 |
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| 作者单位： | 天津药物研究院 天津市新药设计与发现重点实验室;天津中医药大学中医药研究院;天津医科大学 天津医科大学研究生院 |
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| 基金项目： | 国家重大新药创制专项(2011ZX09401-009);天津市科技支撑计划重点项目(10ZCKFSH01300) |
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| 摘 要： | 黑色素瘤由于转移性强,成为皮肤癌中死亡率最高的恶性肿瘤之一,目前没有有效的治疗方法。凝血酶蛋白酶激活受体-1(PAR-1)在黑色素瘤的发病过程中起到重要作用,PAR-1通过激活肿瘤细胞黏附和侵袭以及新生血管因子生成促进黑色素瘤转移。PAR-1有望成为治疗转移性黑色素瘤药物新靶点。
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| 关 键 词： | 凝血酶蛋白酶激活受体-1 黑色素瘤 靶点 |
Advances in PAR-1 as potential therapeutic targets for metastatic melanoma treatment |
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| ZHOU Zhi-xing,ZHANG Yue,PAN Ting-ting,XU Wei-ren.Advances in PAR-1 as potential therapeutic targets for metastatic melanoma treatment[J].Drug Evaluation Research,2012(4):276-280. |
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| Authors: | ZHOU Zhi-xing ZHANG Yue PAN Ting-ting XU Wei-ren |
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| Institution: | 1.Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 2.Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 3.Graduate school of Tianjin Medical University,Tianjin 300070,China |
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| Abstract: | Melanoma remains as the deadliest form of skin cancer with limited and inefficient treatment options available for patients with metastatic disease.The thrombin receptor,Protease Activated Receptor-1,has been considered to play an important role in the progression of human melanoma.PAR-1 is known to activate adhesive,invasive and angiogenic factors to promote melanoma metastasis.This review is about the advance in the research of PAR-1as a potential target of metastatic melanoma. |
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| Keywords: | Protease Activated Receptor-1 melanoma Target |
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