22例卵巢甲状腺肿临床病理分析

目的探讨卵巢甲状腺肿的临床及病理组织学特征。方法回顾性分析22例卵巢甲状腺肿的临床和病理学特征,并对手术标本进行免疫组织化学染色。结果本病发病年龄25～75岁,常见症状为盆腔包块和腹部不适,8例合并腹腔积液,3例血清CA125升高。22例卵巢甲状腺肿为包膜完整结节,21例组织学表现与颈部甲状腺组织的病变相似,镜下见甲状腺滤泡样结构,1例为甲状腺乳头状癌结构。免疫组化显示:20例肿瘤细胞甲状腺球蛋白抗体阳性。结论卵巢甲状腺肿是一种高度特殊化的单胚层畸胎瘤,可出现甲状腺的各种组织学形态,罕见,临床表现无特异性,术前及术中诊断比较困难,预后良好。

Clinicopathologic Study of Struma Ovarii in 22 Patients

Objective To investigate the clinical and pathological features of struma ovarii.Methods The clinical and pathological features of 22 cases of struma ovarii were studied by retrospective analysis.Results The age of the patients ranged from 25 to 75.The most common symptom were cavitas pelvis palpable masses and discomfort.8 cases were associated with ascetic.We observered elevated CA125 levels in 3 cases.The 22 cases of struma ovarii had an intact smooth capsular surface.The morphological characteristic was similar to those of orthotopie thyroid and the tumor consisted with thyroid follicle structure in 21 cases.One case was malignant struma which partially showed thyroid type papillary carcinoma.Immunohistochemistry stain for thyroglobulin antibody was positive in 20 cases.Conclusion Struma ovarii is an rare ovarian monodermal teratoma and all pathological features of thyoid gland could emerge in it.There are difficulties in the clinical diagnosis because of the absence of uniform diagnostic criteria with the rarity of the disease.