瞬时波强技术评价2型糖尿病早期左心室功能的临床研究

目的应用瞬时波强技术(WI)检测2型糖尿病早期患者的左心室功能变化,探讨其临床应用价值。方法选择左室射血分数(EF)≥50%的单纯2型糖尿病组(T2DM)21例和糖尿病合并高血压病组(T2DM+EH)25例,正常对照组25例,均行常规超声心动图和颈动脉WI检测,对比分析3组受试者各项指标的差异。结果 T2DM组与对照组比较:收缩晚期瞬时减速度波强(W2)明显增高(P<0.01),收缩早期瞬时加速度波强(W1)增高(P<0.05),W1顶点到W2顶点的时间(W1～W2)明显缩短(P<0.01)。T2DM+EH组与对照组比较:W1明显增高(P<0.01),W2增高(P<0.05)。T2DM+EH组与T2DM组比较:W1增高(P<0.05),W2呈降低趋势,但差异无统计学意义(P>0.05)。结论瞬时波强技术可以无创检出糖尿病早期患者左心室功能损害,具有重要的临床应用价值。

Clinical Study on Assessement of Left Ventricular Function in Patients with Early Type 2 Diabetes Mellitus with Wave Intensity

Objective To investigate the clinical value of wave intensity(WI) in assessing left ventricular function of patients with early type 2 diabetes mellitus and combined with hypertension.Methods Twenty-one patients with type 2 diabetes mellitus(T2DM) and 25 T2DM patients combined with essential hypertension group(T2DM+EH) were enrolled in this study,and 25 healthy volunteers were taken as control group.Each patient underwent echocardiographic and WI exam.The indexes of conventional echocardiography and WI including W1,W2,R-W1 and W1-W2 of right common carotid artery(CCA) in three groups were measured and compared.Results Prorsad expanded wave peak W2 in T2DM group increased more obviously than that in the control group(P<0.01).Prorsad compressed wave peak Wl in T2DM group was higher than that in control group(P<0.05).Time of W1-W2 in T2DM group was significantly shortened compared with control group(P<0.01).Compared with the control group,Wl in T2DM+EH group was more obviously higher(P<0.01),and W2 increased significantly(P<0.05).Wl in T2DM+EH group was higher than that in T2DM group(P<0.05).W2 in T2DM+EH group reduced than that in T2DM group,but no statistically significant difference was found between the two groups.Conclusion WI can be used as a new method to evaluate left ventricular dysfunction in patients with type 2 diabetes mellitus and T2DM combined with EH.