| 中药金樱子叶的化学成分研究 |
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| 引用本文： | 吴建林,王平,高鹏,曾娜,刘香芳,王书一,沈阳,徐超斗. 中药金樱子叶的化学成分研究[J]. 药学实践杂志, 2012, 30(4): 275-278 |
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| 作者姓名： | 吴建林 王平 高鹏 曾娜 刘香芳 王书一 沈阳 徐超斗 |
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| 作者单位： | 山东中医药大学;北京同仁堂药材公司;上海市儿童医院;总后勤部卫生部药品仪器检验所 |
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| 摘 要： | 目的研究金樱子Rosa Laevigata Michx.嫩叶的化学成分。方法运用硅胶柱色谱、凝胶柱色谱（Sephadex LH-20）以及半制备高效液相色谱等多种现代色谱技术进行分离纯化,根据理化性质和波谱分析鉴定化合物结构。结果从金樱子叶的70%乙醇提取物乙酸乙酯部位分离鉴定得到12个化合物,分别为儿茶素（1）、槲皮素（2）、柚皮素（3）、山柰酚（4）、没食子酸乙酯（5）、对羟基肉桂酸乙酯（6）、ω-hydroxypropioquaiacone（7）、3,4-二羟基苯乙醇（8）、邻羟基苯甲酸（9）、莨菪亭（10）、乙基-α-D-呋喃阿拉伯糖苷（11）、甲基-O-β-D-葡萄糖苷（12）。结论化合物11为首次从蔷薇属植物中分离得到,化合物3、5～9为首次从金樱子叶中分离得到。
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| 关 键 词： | 金樱子叶 化学成分 提取分离 结构鉴定 |
| 收稿时间： | 2012-03-15 |
| 修稿时间： | 2012-06-10 |
Studies on the chemical constituents in leaves of Rosa Laevigata Michx |
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| WU Jian-lin,WANG Ping,GAO Peng,ZENG N,LIU Xiang-fang,WANG Sui-yi,SHEN Yang and XU Chao-dou. Studies on the chemical constituents in leaves of Rosa Laevigata Michx[J]. The Journal of Pharmaceutical Practice, 2012, 30(4): 275-278 |
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| Authors: | WU Jian-lin WANG Ping GAO Peng ZENG N LIU Xiang-fang WANG Sui-yi SHEN Yang XU Chao-dou |
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| Affiliation: | 1.Shandong University of Traditional Chinese Medicine,Jinan 250355,China;2.Beijing Tongrentang Herbal Medicine Company,Beijing 100035,China;3.Shanghai Children′s Hospital,Shanghai 200040,China;4.Institute For Drug and Instrument Control of PLA,Beijing 100071 China) |
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| Abstract: | Objective To investigate the chemical constituents from leaves of Rosa Laevigata Michx.Methods The chemical constituents were isolated and purificated by silica gel column chromatography,Sephadex LH-20 and semi-preparative RP-HPLC.Their structures were identified by spectral data together with physicochemical analysis.Results Twelve known compounds were isolated and identified as catechin(1),quercetin(2),naringenin(3),kaempferol(4),ethyl gallate(5),p-hydroxyl ethyl cinnamate(6),ω-hydroxypropioquaiacone(7),hydroxytyrosol(8),o-hydroxybenzoic acid(9),scopoletin(10),ethyl α-D-arabinofuranoside(11),methyl β-D-glucopyranoside(12).Conclusion Compound 11 was isolated from genus Rosa for the first time,compounds 3,5~9 were isolated from leaves of Rosa Laevigata Michx for the first time. |
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| Keywords: | Leaves of Rosa Laevigata Michx chemical constituents isolation structure identification |
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