| 膀胱尿路上皮癌中miRNA-300的差异表达 |
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| 引用本文： | 徐锋,高建平,张征宇,葛京平,位志峰,程文. 膀胱尿路上皮癌中miRNA-300的差异表达[J]. 医学研究杂志, 2012, 41(1): 39-42 |
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| 作者姓名： | 徐锋 高建平 张征宇 葛京平 位志峰 程文 |
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| 作者单位： | 210002,南京军区南京总医院泌尿外科 |
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| 基金项目： | 国家自然科学基金资助项目(30772278);南京军区南京总医院青年课题(2009-2011) |
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| 摘 要： | 目的探讨miRNA-300在膀胱尿路上皮癌中的差异表达与其生物学行为的关系。方法常规提取30例膀胱尿路上皮癌及5例正常膀胱黏膜组织中总RNA,应用荧光定量RT-PCR方法检测标本中miRNA-300的表达情况。结果与正常膀胱黏膜上皮组织相比,膀胱尿路上皮癌中miRNA-300表达明显下调(P<0.01)。结论 miRNA-300的差异表达极可能为促进膀胱尿路上皮癌的发生及发展因素之一。
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| 关 键 词： | miRNA-300 膀胱尿路上皮癌 实时荧光定量 |
| 收稿时间： | 2011-01-27 |
| 修稿时间： | 2011-03-16 |
Expression of miRNA-300 in Urothelial Carcinoma of the Bladder |
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| Xu Feng , Gao Jianping , Zhang Zhengyu , Ge Jingping , Wei Zhifeng , Cheng Wen. Expression of miRNA-300 in Urothelial Carcinoma of the Bladder[J]. Journal of Medical Research, 2012, 41(1): 39-42 |
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| Authors: | Xu Feng Gao Jianping Zhang Zhengyu Ge Jingping Wei Zhifeng Cheng Wen |
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| Affiliation: | .Department of Urology Surgery,Nanjing General Hospital of Nanjing Military Command PLA,Jiangsu 210002,China |
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| Abstract: | Objective To investigate the gene expression disparity and its relationship with biological behavior of miRNA-300 in urothelial carcinoma of the bladder(BUC).Methods Thirty BUC and five normal bladder mucosa tissues were collected and the total RNA was extracted routinely.The miRNA-300 expression was detected by using real-time quantitative polymerase chain reaction.Results The expression of miRNA-300 was significantly down-regulated in BUC tissues than those in normal bladder mucosa.Conclusion miRNA-300 may Participate in the pathogenesis and development of BUC. |
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| Keywords: | miRNA-300 Urothelial carcinoma of the bladder Real-time quantitative |
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