MSCT灌注成像低剂量扫描对周围型非小细胞肺癌的病理分级的评价

目的探讨MSCT灌注成像低剂量扫描评价周围型非小细胞癌(non-small cell lung cancer,NSCLC)的病理分级的价值。方法 2009年9月～2011年2月期间经病理证实的周围型癌患者26例行MSCT灌注扫描,用Mann-Whitney法比较高、中分化程度及低分化、未分化肺癌的各参数差异,并运用Spearman相关分析有明显差异的灌注值与分化程度的相关性。结果高、中分化的肺癌的BF、PH高于低分化或未分化的肺癌,T1SPN-T1AA低于低分化或未分化的肺癌,其差异均有统计学意义(P<0.05)。BV、PS、MTT及T2SPN-T2AA无明显统计学差异(P>0.05)。肺鳞癌与肺腺癌之间诸参数值无明显统计学意义(P>0.05)。血流量(bllod flow,BF)、强化峰值(peak high,PH)与肺癌分化程度高低具有显著相关性(r分别为-0.398,-0.513,P<0.05)。结论 CT灌注成像低剂量扫描能有效地反映肺癌的分化程度,诸灌注参数中BF、PH、T1SPN-T1AA评价NSCLC的分化程度有一定帮助,其中BF和PH与肺癌分化程度具有显著相关性。

Low-dose MSCT Perfusion Imaging for Evaluation of Tumor Differentiation in Peripheral NSCLC

Objective To investigate the role of low-dose CT perfusion imaging in evaluation of of tumor differentiation in peripheral NSCLC.Methods Twenty-six patients of peripheral lung cancer received CT perfusion fromy September 2009 to February 2011.CT perfusion parameters between moderate or well differentiated and poor differentiated or undifferentiated group were analyzed by using Mann-Whitney test.Then the spearman correlation analysis was made between CT perfusion parameters with statistical significance and tumor differentiation.Results Moderate or well differentiated lung cancers had higher BF,PH and lower T1SPN-T1AA than poor differentiated or undifferentiated lung cancers(P<0.05).CTP parameters between adenocarcinoma and squamous carcinoma had no statistical difference(P>0.05).There was positive correlation between BF,PH and tumor differentiation(r=-0.398,-0.513,respectively,P<0.05).Conclusions The low-dose MSCT perfusion imaging is an effective method for reflecting the differentiation of lung cancer.BF,PH,T1SPN-T1AA in CT perfusion parameters is helpful.Especially,there is positive correlation between BF,PH and tumor differentiation(P<0.05).