| 注射用卡络磺钠与4种常用输液的配伍稳定性 |
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| 引用本文： | 张海红,刘放.注射用卡络磺钠与4种常用输液的配伍稳定性[J].药学实践杂志,2012,30(5):365-368. |
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| 作者姓名： | 张海红 刘放 |
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| 作者单位： | 浙江省嵊泗县人民医院药剂科;浙江省医学科学院药物研究所 |
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| 摘 要： | 目的研究室温6 h内注射用卡络磺钠与5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液和复方葡萄糖氯化钠注射液的配伍稳定性,为临床用药提供科学依据。方法采用紫外分光光度法和反相高效液相色谱法分别测定注射用卡络磺钠与上述4种输液配伍后,6 h内卡络磺钠的含量及有关物质,同时考察配伍液的外观和pH值。结果在室温条件下,注射用卡络磺钠与上述4种输液配伍6 h后,外观、pH值、含量和有关物质均无明显变化。结论注射用卡络磺钠可与上述4种注射液配伍使用。
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| 关 键 词： | 注射用卡络磺钠 输液 配伍稳定性 反相高效液相色谱 紫外分光光度法 |
| 收稿时间： | 2011/12/12 0:00:00 |
| 修稿时间： | 2012/3/27 0:00:00 |
The stability of compatibility of carbazochrome sodium sulfonate with four transfusions in common use |
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| ZHANG Hai-hong and LIU Fang.The stability of compatibility of carbazochrome sodium sulfonate with four transfusions in common use[J].The Journal of Pharmaceutical Practice,2012,30(5):365-368. |
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| Authors: | ZHANG Hai-hong and LIU Fang |
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| Institution: | 1.Department of Pharmacy,Zhejiang ShengSi People′s Hospital,Shengsi 202450,China;2.Institute of Matera Medica,Zhejiang Academy of Medical Sciences,Hangzhou 310013,China) |
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| Abstract: | Objective To study the stability of compatibility of carbazochrome sodium sulfonate with four different transfusions for 6 hours at room temperature.Methods The content and related substances of carbazochrome sodium for sulfonate injection in four mixture were determined by UV spectrophotometric and HPLC.The appearance and pH values were determined.Results TThe results showed that there was no significant changes after matching in the appearance,pH values,content and related substances for 6 hours at room temperature.Conclusion Carbazochrome sodium sulfonate for injection could be combined with 5% glucose injection,10% glucose injection,0.9% sodium chloride injection,glucose and sodium choloride injection. |
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| Keywords: | carbazochrome sodium sulfonate for injection infusions compatibility stability RP-HPLC UV spectrophotometric methods |
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