雷珠单抗和康柏西普对老年湿性黄斑病变的疗效比较

目的:探究雷珠单抗和康柏西普对老年湿性黄斑病变的疗效比较。方法:选取48例老年湿性黄斑病变患者,按患者入院先后顺序将患者分为对照组(n=24)和研究组(n=24)。对照组患者给予雷珠单抗治疗,研究组患者给予康柏西普治疗,对比两种药物的疗效。结果:研究组患者在治疗第1个月的视力为(0.29±0.10),对照组为(0.38±0.08),差异有统计学意义(P<0.05);研究组患者第1个月黄斑中心凹视网膜厚度为(355.2±52.6)μm,对照组为(345.5±53.3)μm,差异有统计学意义(P<0.05);研究组患者脉络膜新生血管(choroidal neovascularisation,CNV)渗透的复发率低于对照组,治疗有效率高于对照组(P<0.05);研究组患者的注射次数为(4.79±1.26)次,对照组患者的注射次数为(4.01±1.01)次,差异有统计学意义(P<0.05)。结论:康柏西普治疗老年湿性黄斑病变患者的前期效果优于雷珠单抗,后期效果相当,但康柏西普可降低患者CNV渗透的发生几率,且注射次数少,具有较高的临床应用价值。

Efficacy comparison of rezumumab and compacept in the treatment of se-nile wet macular degeneration

Objective:To compare the efficacy of Ranibizumab and compacept in the treatment of senile wet macular degenera-tion.Methods:48 cases of patients with senile wet macular degenerationwere selected as research subjects.The patients were divided into control group (n=24) and study group (n=24) according to admission order.The control group was treated with Ranibizumab treatment,the study group was treated with Compacept treatment,the efficacy of the two medications was compared.Results:The vision of the patients in the study group was (0.29+0.10) at the first month after the operation,the control group was (0.38+0.08),the difference was statistically significant(P<0.05).In the study group,the retinal thickness of macular fovea was(355.2+52.6)μm at the first month,and the control group was (345.5+53.3)μm,the difference was statistically significant (P<0.05).The recurrence rate of CNV in the study group was lower than those in the control group,and the effective rate was higher than the control group(P<0.05).The number of injections in the study group was(4.79+1.26) times,the number of injections in the control group was(4.01+1.01) times,the difference was statistically significant (P<0.05).Conclusions:The effect of compacept in the treatment of senile wet macular degeneration is better than rezumab,and the effect is equal to the latter.However,compacept can reduce the incidence of CNV infiltration in patients with fewer injection times,and has a high clinical value.