| 自发性蛛网膜下腔出血早期脑损伤动物模型的建立 |
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| 引用本文： | 范高阳,王业忠,许晖,刘祺,姬云翔,田卫东,姚俊岭,赵冬.自发性蛛网膜下腔出血早期脑损伤动物模型的建立[J].中国微侵袭神经外科杂志,2011,16(5):227-230. |
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| 作者姓名： | 范高阳 王业忠 许晖 刘祺 姬云翔 田卫东 姚俊岭 赵冬 |
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| 作者单位： | 新疆石河子大学医学院第一附属医院神经外科,832008 |
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| 摘 要： | 目的 建立一种蛛网膜下腔出血(SAH)后早期脑损伤动物模型.方法 选用新西兰大耳白兔60只,随机分为实验组36只,对照组18只,空白组6只.实验组采用枕大池穿刺一次注入自体动脉血法建立SAH模型,对照组注入平衡液,空白组仅行枕大池穿刺.在造模后4、8、12、24、48、72 h,观察比较各组动物神经功能改变和脑组织形态学变化.结果 肉眼观察实验组造模后见蛛网膜下腔大量血凝块或血液,光镜和电镜下见蛛网膜下腔大量红细胞,神经细胞水肿、变性;对照组和空白组无异常.实验组注血后出现明显的神经行为学症状;与对照组比较,实验组神经功能评分在8～72h明显升高(P<0.01);与空白组比较,实验组神经功能评分在各时间点均明显升高(P<0.01).结论 枕大池一次注入自体动脉血法建立自发性SAH模型简便、可重复,适宜于研究SAH后早期脑损伤.
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| 关 键 词： | 蛛网膜下腔出血 颅脑损伤 模型 动物 兔 |
Establishment of early brain injury model after spontaneous subarachnoid hemorrhage in rabbits |
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| Fan Gaoyang,Wang Yezhong,Xu Hui,Liu Qi,Ji Yunxiang,Tian Weidong,Yao Junling,Zhao Dong.Establishment of early brain injury model after spontaneous subarachnoid hemorrhage in rabbits[J].Chinese Journal of Minimally Invasive Neurosurgery,2011,16(5):227-230. |
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| Authors: | Fan Gaoyang Wang Yezhong Xu Hui Liu Qi Ji Yunxiang Tian Weidong Yao Junling Zhao Dong |
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| Institution: | Fan Gaoyang,Wang Yezhong,Xu Hui,Liu Qi,Ji Yunxiang,Tian Weidong,Yao Junling,Zhao Dong Department of Neurosurgery,First affiliated Hospital,Medical College of Shihezi University,Shihezi,Xinjiang 832008,China |
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| Abstract: | Objective To establish a new animal model of early brain injury after symptomatic subarachnoid hemorrhage(SAH) in rabbits.Methods Sixty rabbits were divided randomly into 3 groups: 36 rabbits in experimental group,18 in control group and 6 in blank group.SAH models were set up through the method for cisternal puncturing and one-time injecting autologous arterial blood in experimental group,while injection of balanced solution was performed in control group and only cisternal puncture in blank group.The neur... |
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| Keywords: | subarachnoid hemorrhage craniocerebral trauma models animal rabbits |
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