Effects of bisphosphonate on trabecular microstructure

Bisphosphonate is known to be deposited in resorption area. In our small animal study to evaluate the effect of bisphosphonate on trabecular microstructure, micro-CT demonstrated the different trabecular microstructure among the sham, ovariectomized (OVX) rats and the OVX rats which were treated with risedronate (0.1, 0.5, 2.5 mg/kg) or menatetrenone 30 mg/kg, or with the combination of risedronate 0.5 mg/kg and menatetrenone 30 mg/kg. The pattern of change on trabecular microstructure was also different between risedronate and menatetrenone; risedronate maintained trabecular connectivity, whereas menatetrenone thickened the trabeculae. The combination therapy with menatetrenone provided an additional improvement of trabecular microstructure to the single use of risedronate.