瑞芬太尼微量输注用于甲状腺手术的效价评估

目的:探讨瑞芬太尼持续微量静脉输注辅助颈丛神经阻滞用于甲状腺手术的安全性和有效性。方法:颈丛阻滞麻醉下行双侧甲状腺次全切除术60例。对照组静脉注射咪唑地西泮0.03 mg/kg,芬太尼0.01 mg/kg;试验组瑞芬太尼0.01～0.08μg/kg.min持续微量静脉输注。比较术中两组MAP、HR、SpO2及RR各值变化。对比两组患者镇静、镇痛程度的差异。结果:①试验组血流动力学稳定;对照组MAP、HR于T2、T3时点较术前和试验组比较差异有统计学意义(P<0.05)。②对照组镇静优良率60%,镇痛优良率仅70%。试验组患者镇静镇痛优良率均达90%以上。两组比较差异有统计学意义(P<0.01)。结论:瑞芬太尼持续微量静脉输注用于甲状腺手术辅助麻醉是安全可行的。

Clinical observation of microdosis remifentanil used in thyroid surgery

Objective To investigate the effect and safety of microdosis remifentanil-assisted cervicals plexus nerve block for thyroid surgery.Method Total 60 cases of thyroid surgery patients,were treated with cervicals plexus nerve block anesthesia,who were randomly divided into two groups.The control group was give midazolam（0.03 mg/kg） and fentangl（0.01 mg/kg） of intravenous injection.The experimental group was followed by remifentanil 0.01~0.08 μg/（kg·min）] continued minimally.In both groups,observing the changes of MAP,HR,SpO2 and RR and contrasting the difference of the degrees of calm and analgesia.Results ①In the experimental group,patients′ haemodynamics was stabilizer than that in the control group.②The fineness rate of the degrees of calm and analgesia were 60% and 70% in the control group.But they were 90% above.In the experimental group,the significant difference was existent between the two groups.Conclusion Microdosis remifentanil is safe and feasible as the auxiliary anesthesia method of thyroid surgery.