老年慢性阻塞性肺疾病血清白细胞介素-13的变化

目的　探讨白细胞介素 13 (IL 13 )与慢性阻塞性肺疾病 (COPD )的关系。方法　用双抗夹心ABC ELISA法测定 3 5例老年COPD患者 (急性加重期 2 0例 ,稳定期 15例 )血清IL 13水平 ,并与 2 2名健康者 (对照组 )进行比较。结果　老年COPD急性加重期组 ,COPD稳定期组和对照组血清IL 13水平分别为 (4 7.2 6± 3 .47) pg/ml、(3 6.11± 5 .3 4)pg/ml和 (3 0 .99± 2 .19) pg/ml。COPD急性加重期组和COPD稳定期组血清IL 13水平均显著高于对照组 (P <0 .0 5 ) ,且COPD急性加重期组血清IL 13水平显著高于COPD稳定期组 (P <0 .0 5 )。结论　老年COPD患者血清中IL 13水平显著升高 ,IL 13与COPD的发生发展有关

Changes of serum levels of IL-13 in old patients with chronic obstructive pulmonary disease

Objective To investigate the changes of serum levels of interleukin-13(IL-13)in old patients with chronic obstructive pulmonary disease(COPD).Methods 57 cases were divided into three groups:acute COPD exacerbation group( n =20),stable COPD group( n =15)and control group( n =22).The serum levels of IL-13 were detected in all cases.Results Both the plasma IL-13 concentrations of acute COPD exacerbation group and of stable COPD group were marking higher than that of control group( P < 0.05). The levels of acute COPD exacerbation group was marking higher than that of COPD stable group( P <0.05).Conclusion IL-13 may have effect on pathogenesis of COPD and it may play an important role in the progress of infection which lead to the acute COPD exacerbation.