血清TPS 与肝细胞肝癌临床病理特征的相关性探讨

 目的 探讨血清组织多肽特异性抗原(TPS)与肝细胞肝癌(HCC)临床病理特征的相关性。方法 采用酶联免疫吸附法，分别测定74例HCC患者、35例肝硬化患者、22例慢性肝炎患者和42例健康人体血清TPS和AFP水平。分析TPS与HCC临床病理特征的相关性，并与AFP比较。结果 HCC组TPS血清水平仅高于正常对照组(P<0．05)．与肝硬化及肝炎组比较无显著性差异(P>0．05)；TPS与DB、IB、ALT、AST、γ-GT、LDH以及肿瘤大小之间存在显著相关性(P<0．05)，但与肿瘤数目、门脉癌栓、肝外转移、临床分期及肿瘤分化程度均无显著相关性(P>0．05)；AFP与肿瘤大小、门脉癌栓及肿瘤分化程度之间存在显著相关性(P<0．05)。结论 血清TPS与HCC肿瘤侵袭性之间无显著相关性，但与肝功能受损程度相关性显著，因此必须谨慎对待肝病患者血清TPS的升高。

Clinicopathologic Correlation of Serum Tissue Polypeptide Specific Antigen in Hepatocellular Carcinoma

Objective 　To clarify the clinicopathologic correlation of serum tissue polypeptide specific antigen ( TPS) in hepatocellular carcinoma ( HCC) . Methods 　The serum levels of TPS and AFP were measured by EL ISA in 74 HCC patients , 35 patient s with liver cirrhosis , 22 patients with chronic hepatitis and 42 healthy subjects. A correlation between serum TPS levels and clinical , biochemical , and pathological features in HCC was sought and compared with that of AFP. Results 　Patient s with HCC had significantly higher TPS than healthy subject s ( P < 0. 05) . However , there was substantial overlap between patients with HCC , chronic hepatitis ,and liver cirrhosis. Serum TPS levels were significantly correlated with direct bilirubin (DB) , indirect bilirubin ( IB) , alanine aminot ransferase (ALT) , aspartate aminot ransferase (AST) ,γ-glutamyl t ransferase (γ-GT) , lactate dehydrogenase (LDH) and tumor size ( P <0. 05) , but not with tumor number , portal invasion , ext rahepatic metastasis , clinical staging and histological differentiation ( P > 0. 05) . A significant correlation was observed between AFP and tumor size ( P= 0. 047) , portal invasion ( P= 0. 029) or histological differentiation ( P = 0. 000) . Conclusion 　Serum TPS isn’t significantly related to tumor invasiveness in patient s with HCC , but related to liver function. So we must interpret its presence in chronic liver disease cautiously.