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| 胃内滞留漂浮给药系统中使用草药根除幽门螺旋杆菌的研究进展 | |
| 引用本文： | Nirav V. PATEL. 胃内滞留漂浮给药系统中使用草药根除幽门螺旋杆菌的研究进展[J]. 中西医结合学报, 2009, 7(10): 976-982. DOI: 10.3736/jcim20091012 |
| 作者姓名： | Nirav V. PATEL |
| 作者单位： | Shreeraj H. SHAH(Department of Pharmaceutics, Lok Jagruti Institute of Pharmacy, Gujarat University, Ahmedabad 382 210, Gujarat, India);Jayvadan K. PATEL(Department of Pharmaceutics, Nootan Pharmacy College, North Gujarat Hemchandracharya University, Visnagar 384 315, North Gujarat, India);Nirav V. PATEL(Department of Pharmaceutics, Anand College of Pharmacy, Sardar Patel University, Anand 388 001, Gujarat, India) |
| 基金项目： | Acknowledgement I would like to acknowledge Dr. K. Pundarikakshudu for giving constant help to compile the information and in preparation of this article. I am also very much thankful to Prof. B. M. Peerzada and Prof. Manish Shah for constant encouragement. |
| 摘 要： | Helicobacter pylori are very common pathogenic bacteria colonizing about half of all populations and associated with the development of serious gastroduodenal diseases like gastric lymphoma, peptic ulcers and acute chronic gastritis. Current drug regimes are not wholly effective. Other problems related with the current drug regimes are lack of patient compliance, side effects and bacterial resistance. Thus, drug deliyery to the site of residence in the gastric mucosa may help in solving the problems associated with the current drug therapy. Gastric retentive delivery systems potentially allow increased penetration and thus increased drug concentration at thesite of action. |
| 关 键 词： | 幽门螺旋杆菌 胃滞留剂 漂浮剂型 草药 黑柯子 黄连素 |
Gastroretentive floating drug delivery systems with potential herbal drugs for Helicobacter pylori eradication: a review |
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| Shreeraj H. SHAH,Jayvadan K. PATEL,Nirav V. PATEL. Gastroretentive floating drug delivery systems with potential herbal drugs for Helicobacter pylori eradication: a review[J]. Journal of Chinese integrative medicine, 2009, 7(10): 976-982. DOI: 10.3736/jcim20091012 | |
| Authors: | Shreeraj H. SHAH Jayvadan K. PATEL Nirav V. PATEL |
| Affiliation: | 1. Department of Pharmaceutics, Lok Jagruti Institute of Pharmacy, Gujarat University, Ahmedabad 382 210, Gujarat, India 2. Department of Pharmaceutics, Nootan Pharmacy College, North Gujarat Hemchandracharya University, Visnagar 384 315, North Gujarat, India 3. Department of Pharmaceutics, Anand College of Pharmacy, Sardar Patel University, Anand 388 001, Gujarat, India |
| Abstract: | Helicobacter pylori are very common patho-genic bacteria colonizing about half of all populations and associated with the development of serious gastroduodenal diseases like gastric lym-phoma, peptic ulcers and acute chronic gastritis. Current drug regimes are not wholly effective. Other problems related with the current drug regimes are lack of patient compliance, side effects and bacterial resistance. Thus, drug delivery to the site of residence in the gastric mucosa may help in solving the problems associated with the current drug therapy. Gastric retentive delivery systems potentially allow increased penetration and thus increased drug concentration at the site of action. Floating drug delivery systems, expandable or swellable drug delivery systems and bioadhesive systems are the major areas of interest to formulate gastroretentive drug delivery system against H. pylori. |
| Keywords: | Helicobacter pylori gastroretentive dosage forms floating dosage forms herbal drugs black myrobalan berberine |
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