高敏C反应蛋白和胆红素对冠心病患者病情的判断价值

目的评价血清高敏C-反应蛋白（hs-CRP）与胆红素（BIL）对冠心病患者临床病情的判断价值。方法测定血清hs-CRP与BIL水平，结合冠状动脉造影，对冠心病患者临床病情进行分析评价。结果冠心病组不稳定型心绞痛（UAP）和急性心肌梗死（AMI）患者的hs-CRP水平明显高于稳定型心绞痛（SAP）组和正常对照组（JP〈0．01或P〈0．05）冠心病组UAP、AMI患者的总胆红素（TBIL）水平明显低于SAP组和正常对照组（P〈0．01或P〈0．05）冠脉病变范围越大hs-CRP水平越高，BIL水平越低。结论血清hs-CRP可较灵敏地反映冠心病患者病情程度，可能为不稳定斑块的指示因子；血清总胆红素浓度减低可能在CHD的发病中具有一定的作用。

Effect of High Sensitive C-Reactive Protein and Bilirubin in Patients with Coronary Heart Disease

Objective To investigate the correlation between the serum levels of high sensitive C - reactive protein （hs-CRP） and bilirubin （BIL） in patients with coronary heart Disease.Methods Serum hs-CRP and BIL were measured in patients.Combined with coronary angiography ,the clinical severity was assessed.Results The serum levels of hs-CRP in UAP and AMI patients with coronary heart disease were all significantly higher than that in SAP and normal people （P〈0.05,P〈0.01）; The serum levels of TBIL in UAP and AMI patients with coronary heart disease were all significantly lower than that in SAP and normal people （P〈0.05,P〈0.01）.Correlation between the serum levels of higher hs-CRP and lower TBIL with coronary artery lesions.Conclusion The present study indicates that the serum levels of hs-CRP may be a risk factor of coronary heart disease,it can reflect the clinical severity,and may mark unstable atherosclerotic plaque in patients with coronary heart disease. The serum levels of lower TBIL may play an important role in patients with coronary heart disease.