| ROLE OF COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR （CAR） IN CARDIOTOXICITY INFECTED BY COXSACKIEVIRUS B3 |
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| 引用本文： | 赵武,周爱卿,傅立军,梁瑛,唐宁.ROLE OF COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR （CAR） IN CARDIOTOXICITY INFECTED BY COXSACKIEVIRUS B3[J].上海第二医科大学学报,2005,17(2):128-131. |
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| 作者姓名： | 赵武 周爱卿 傅立军 梁瑛 唐宁 |
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| 作者单位： | [1]Department of Pediatric Cardiology, Shanghai Institute for Pediatric Research, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China |
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| 摘 要： | Objective To explore the role of coxsackievirus and adenovirus receptor（CAR） in cardiotoxicity infected by coxsackieviras B3. Methods A toxic cellular model was established in vitro by adding myocarditic coxsackievirus B3 （CVB3m） into the culture of neonatal mouse cardiomyocytes. 48 h later, the cardiomyocytes were divided into control, CVB3m, and CAR antibody ＋ CVB3m groups. CVB3m-mediated myocytopathic effect of above three groups was observed after further culturing for 48h. At the same time, the cardiomyocytes＇ viability of above three groups was assessed by MTT assay. Results The degree of cytopathic effect（CPE） of CAR antibody ＋ CVB3m group was significantly lower than CVB3m group （ P 〈 0. 01 ） and there was a significant increase in cell viability in CAR antibody ＋ CVB3m group compared with CVB3m group（ P 〈 0. 01 ）. No significant difference was found between CAR antibody ＋ CVB3m group and control group. Conclusion CAR antibody possesses a protective effect on CVB3m infected cardiomyoctyes, which indicates that CAR may play an important role in mediating cardiotoxicity infected by CVB3m.
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| 关 键 词： | 腺病毒 病毒感染 病毒性心肌炎 柯萨奇病毒B3 |
| 收稿时间： | 2004-07-27 |
ROLE OF COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR ( CAR)IN CARDIOTOXICITY INFECTED BY COXSACKIEVIRUS B3 |
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| Zhao Wu;Zhou AiQing;Fu LiJun;Liang Ying;Tang Ning.ROLE OF COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR ( CAR)IN CARDIOTOXICITY INFECTED BY COXSACKIEVIRUS B3[J].Journal of Shanghai Second Medical University(Foreign Language Edition),2005,17(2):128-131. |
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| Authors: | Zhao Wu;Zhou AiQing;Fu LiJun;Liang Ying;Tang Ning |
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| Abstract: | |
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| Keywords: | coxsackievirus and adenovirus receptor(CAR) coxsackievirus B3(CVB3) cardiomyocytes |
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