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Hippocampal volume in borderline personality disorder with and without comorbid posttraumatic stress disorder: A meta-analysis |
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| Authors: | E RodriguesA Wenzel MP RibeiroLC Quarantini A Miranda-ScippaEP de Sena IR de Oliveira |
| Institution: | a Department of Neurosciences and Mental Health, School of Medicine, Federal University of Bahia, Salvador, Brazil b Department of Psychiatry, University of Pennsylvania, Philadelphia, USA c Department of Pharmacology and Physiology, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil |
| Abstract: | BackgroundSeveral studies have found a reduction in hippocampal volume in borderline personality disorder (BPD) patients.MethodsIn order to investigate the degree to which comorbid posttraumatic stress disorder (PTSD) could account for reduction in hippocampal volume in these patients, we conducted a systematic review and meta-analysis of studies that compared hippocampal volume in BPD patients with and without PTSD relative to healthy controls.ResultsSeven articles, involving 124 patients and 147 controls, were included. We found a statistically significant reduction for the left and right hippocampus. Data from the four studies that discriminated BPD patients with and without PTSD indicate that hippocampal volumes were reduced bilaterally in BPD patients with PTSD, relative to healthy controls, but that results were mixed for BPD patients without PTSD, relative to healthy controls.ConclusionsResults from this meta-analysis suggest that hippocampal volumes are reduced in patients with BPD, relative to healthy controls, but particularly in cases in which patients are diagnosed with comorbid PTSD. |
| Keywords: | Borderline personality disorder Hippocampus Meta-analysis Magnetic resonance imaging Posttraumatic stress disorder |
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