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Anomalous behavior of pentacoordinate copper complexes of dimethylphenanthroline and derivatives of terpyridine ligands: Studies on DNA binding, cleavage and apoptotic activity |
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| Authors: | Rajalakshmi Subramaniyam Weyhermüller Thomas Freddy Allen J Vasanthi Hannah R Nair Balachandran Unni |
| Affiliation: | a Chemical Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Adyar, Chennai 600 020, India b Max-Planck Institut für Bioanorganische Chemie, D-45413 Mülheim an der Ruhr, Germany c Herbal and Indian Medicine Research Laboratory, Department of Biochemistry, Sri Ramachandra University, Porur, Chennai 600116, India |
| Abstract: | Copper(II) complexes with substituted terpyridine ligands, namely [Cu(itpy)(dmp)](NO3)2 (1) and [Cu(ptpy)(dmp)](NO3)2 (2) have been synthesized and characterized. The interaction of the complexes with CT-DNA has been explored using spectroscopic techniques and viscosity. Complexes 1 and 2 bind in the grooves of DNA, interestingly 1 in the minor and 2 in the major groove. Both the complexes have been found to promote DNA cleavage; complex 1 through hydrolytic and 2 oxidative. Complexes 1 and 2 have been found to be cytotoxic and bring about apoptosis of human lung cancer cell line A549. |
| Keywords: | Copper complexes DNA binding Groove binder DNA cleavage Cytotoxicity Apoptosis |
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