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Selenium-72 formation via Br(p,x) induced by 100 MeV Protons: Steps towards a novel Se/As generator system |
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| Authors: | B. BallardD. Wycoff E.R. BirnbaumK.D. John J.W. LenzS.S. Jurisson C.S. CutlerF.M. Nortier W.A. TaylorM.E. Fassbender |
| Affiliation: | a Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA b Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA c John Lenz and Associates, East Lansing, MI 48823, USA d Missouri University Research Reactor Center, University of Missouri-Columbia, Columbia, MO 65211, USA |
| Abstract: | Selenium-72 production by the proton bombardment of a natural NaBr target has been successfully demonstrated at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF). Arsenic-72 (half life 26 h) is a medium-lived positron emitting radionuclide with the major advantage of being formed as the daughter of another “generator” radioisotope (Se-72, 8.5 d). A 72Se/72As generator would be the preferred mechanism for clinical utilization of 72As for positron emission tomography (PET). No portable 72Se/72As generator system has been demonstrated for convenient, repeated 72As elution (“milking”). In this work, we describe 72Se production and recovery from irradiated NaBr targets using a 100 MeV proton beam. We also introduce an 72As generator principle based on 72Se chelation followed by liquid-liquid extraction, which will be transferred to a solid-phase sorption/elution system. |
| Keywords: | 72Se/As generator natBr(p,x) reaction NaBr target Thermal analysis 72Se recovery Dithiocarbamate synthesis |
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