2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4

Authors:	Billamboz Muriel Bailly Fabrice Lion Cédric Calmels Christina Andréola Marie-Line Witvrouw Myriam Christ Frauke Debyser Zeger De Luca Laura Chimirri Alba Cotelle Philippe

Affiliation:	^a Université Lille Nord de France, F-59000 Lille, France ^b USTL, EA 4478 Chimie moléculaire et formulation, F-59655 Villeneuve d’Ascq, France ^c Institut Fédératif de Recherches “Pathologies Infectieuses et Cancers” (IFR 66), MCMP-UMR 5234 CNRS, Université Victor Segalen Bordeaux 2, F-33076 Bordeaux, France ^d Molecular Medicine, K.U. Leuven and IRC KULAK, Kapucijnenvoer 33, B-3000 Leuven, Flanders, Belgium ^e Dipartimento Farmaco-Chimico, Universita di Messina, Viale Annunziata, 98168 Messina, Italy

Abstract:

Keywords:	2-Hydroxyisoquinoline-1,3(2H,4H)-dione Integrase Ribonuclease H Magnesium complexation Antiretroviral
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