重症急性胰腺炎患者血清炎性因子含量与全身靶器官损伤的关系研究

目的:研究重症急性胰腺炎(SAP)患者血清炎性因子含量与全身靶器官损伤的关系。方法:选择在本院诊断为重症急性胰腺炎的85例患者作为SAP组,选择同期体检的100例健康志愿者作为对照组,检测血清中炎性因子、肝功能损伤指标、肾功能损伤指标、肠黏膜屏障功指标及尿液中肾功能损伤指标。结果:SAP组血清中PCT、TNF-α、CRP、HMGB-1、ALT、AST、TBIL、BUN、Scr、CysC、DAO、D-乳酸、Occludin、ZO-1的含量及尿液中NGAL、KIM-1的含量均显著高于对照组;SAP患者血清中PCT、TNF-α、CRP、HMGB-1含量与血清中ALT、AST、TBIL、BUN、Scr、CysC、DAO、D-乳酸、Occludin、ZO-1含量及尿液中NGAL、KIM-1含量呈正相关。结论:SAP患者血清中炎性因子的异常释放会引起肝功能、肾功能、肠黏膜屏障功能损伤。

Study on the relationship between serum inflammatory factors and systemic target organ damage in patients with severe acute pancreatitis