Incidence of bilateral testicular germ cell cancer in Denmark, 1960–84: preliminary findings |
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| Authors: | ANNE ØSTERLIND J G BERTHELSEN N ABILDGAARD S O HANSEN H JENSEN B JOHANSEN J MUNCK-HANSEN L H RASMUSSEN |
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| Institution: | The Danish Cancer Registry, Institute of Cancer Epidemiology under the Danish Cancer Society, Landskronagade 66, 4th floor, DK-2100 Copenhagen, Denmark.;Laboratory of Reproductive Biology, Rigshospitalet and Department of Gynaecology and Obstetrics, Herlev Hospital, Copenhagen;Department of Oncology, The Municipal Hospital, Aarhus;Department of Oncology, Odense Hospital, Odense;Department of Oncology, Finsen Institute, Copenhagen;Department of Oncology, Aalborg Hospital, Aalborg;Department of Oncology, Herlev Hospital, Copenhagen, Denmark |
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| Abstract: | The incidence of a second primary testicular germ cell cancer in the contralateral testicle among 2338 men with a first primary testicular germ cell cancer diagnosed in the years 1960-79 in Denmark was established in this preliminary report. The material represents 83% of the total cohort followed until 31 December 1984. The relative risk for a patient with testicular cancer to get yet another testicular cancer was studied, taking into account the histology of the first primary testicular germ cell cancer. Based on fifty-eight nonsimultaneous contralateral testicular cancer cases and 19,995 'person-years at risk', the overall relative risk of invasive germ cell cancer in the contralateral testicle following a first germ cell testicular cancer was found to be 23.3 (95% confidence interval: 18-30). Among men with nonseminoma the risk was higher (relative risk = 27.5) than among men with seminomas (relative risk = 20.1). Overall, sixty-two (2.7%) patients developed a second cancer. In four of these patients bilateral tumours occurred simultaneously. |
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| Keywords: | Cancer incidence germ cell cancer bilateral testicular cancer |
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