细胞信号转导抑制因子与肺部疾病

细胞因子通过活化细胞表面受体复合物而发挥其在调控细胞生物学功能中的重要作用,信号转导被一些负性蛋白严格控制,其中以细胞信号转导抑制因子(SOCS)最为重要,SOCS主要通过抑制JAK/STAT信号通路对细胞因子的作用强度及持续时间进行调控。近几年研究显示,SOCS不仅与全身免疫疾病有关,而且在哮喘、肺癌、急性肺损伤等肺部疾病中起重要作用。

Suppressors of Cytokine Signaling and Pulmonary Diseases

Cytokines can exert their important roles in regulat ing cell biologic al function by activating cell surface receptor complex.Signal transduction o ften can be strictly controlled by negative protein,among which the SOCS is the most important one.SOCS can regulate the effective extent and effecti ve time of sytokines by inhibiting JAK/STAT signal pathway.Recent researche s showed that SOCS not only is related to system immunolgically mediated disea ses,but also plays an important role in many lung diseases including asthm a,lung cancer,acute lung injury and so on.