| 抗新型冠状病毒肺炎(COVID-19)药物潜在相互作用研究进展 |
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| 引用本文： | 叶林虎,徐永寿,邓艳,刘洪,赵欣黔,李炼,谢军,贺梅,王婷婷,王森.抗新型冠状病毒肺炎(COVID-19)药物潜在相互作用研究进展[J].现代药物与临床,2020,35(4):607-613. |
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| 作者姓名： | 叶林虎 徐永寿 邓艳 刘洪 赵欣黔 李炼 谢军 贺梅 王婷婷 王森 |
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| 作者单位： | 毕节市第一人民医院, 贵州 毕节 551700;遵义医科大学 药学院, 贵州 遵义 563000;贵阳市第四人民医院, 贵州 贵阳 550000 |
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| 基金项目： | 贵州省科技支撑项目（黔科合支撑[2020]4Y118号）；贵州省毕节市第一人民医院院士工作站项目（黔科合平台人才[2018]55621-7）；毕节市科技局重点实验室项目（毕科合字[2019]1号）；毕节市医学重点学科项目（毕卫合字[2016]1） |
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| 摘 要： | 自2019年12月以来,国内外暴发了新型冠状病毒肺炎(COVID-19)。在COVID-19的患者中,除了抗病毒治疗外,还要治疗并发症,临床需要采取联合用药的方式进行治疗。虽然在近期发布的指南中多次强调注意抗COVID-19药物间的相互作用,但却无相应的详述。主要对治疗COVID-19药物的潜在相互作用进行综述,以期为COVID-19的临床安全、合理用药提供参考。
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| 关 键 词： | 新型冠状病毒肺炎 药物相互作用 细胞色素P450酶 P-糖蛋白 药物不良反应 中药注射剂 |
| 收稿时间： | 2020/3/23 0:00:00 |
Research progress on potential drug interactions of anti-coronavirus disease 2019 drugs |
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| YE Lin-hu,XU Yong-shou,DENG Yan,LIU Hong,ZHAO Xin-qian,LI Lian,XIE Jun,HE Mei,WANG Ting-ting,WANG Sen.Research progress on potential drug interactions of anti-coronavirus disease 2019 drugs[J].Drugs & Clinic,2020,35(4):607-613. |
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| Authors: | YE Lin-hu XU Yong-shou DENG Yan LIU Hong ZHAO Xin-qian LI Lian XIE Jun HE Mei WANG Ting-ting WANG Sen |
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| Institution: | The First People''s Hospital of Bijie, Bijie 551700, China;Department of Pharmacy, Zunyi Medical University, Zunyi 563000, China;The Fourth People''s Hospital of Guiyang, Guiyang 550000, China |
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| Abstract: | From the December 2019, coronavirus disease 2019 (COVID-19) was outbreak at home and abroad. Besides antiviral therapy, patients should be treated for complications, therefore a combination of drugs for treatment in clinic need to be taken. Although recently published guidelines have repeatedly highlighted the drug interactions between the anti-COVID-19 medicines, it has not been detailed. The potential drug-drug interactions were reviewed of the anti-COVID-19 drugs, and in order to provide references for the clinical safety and rational use of the anti-COVID-19 drugs. |
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| Keywords: | COVID-19 drug interactions cytochrome P450 P-glycoprotein adverse drug reaction traditional Chinese medicine injection |
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