术前应用人工泪液对白内障合并干眼患者术后眼表的影响

目的:探究在白内障超声乳化联合人工晶状体植入术前,应用人工泪液对白内障合并干眼症患者术后泪膜功能及干眼的影响。方法:纳入2018-06/2019-06在我院接受超声乳化联合人工晶状体植入术前合并干眼症的白内障患者107例107眼。随机分为对照组:术前未使用人工泪液;研究组:术前1wk使用0.1%玻璃酸钠人工泪液滴眼液。观察并分析两组患者术前、术后7、30d的临床症状评分、泪膜破裂时间检查(BUT)、基础泪液分泌试验(SⅠt)以及角膜荧光染色评分(FL)情况。结果:两组术前OSDI评分(28.59±8.10 vs 29.08±9.18分)、BUT(5.15±0.47 vs 5.02±0.53s)、SⅠt(6.86±0.98 vs 6.71±1.02mm/5min)、FL评分(3.96±0.89 vs 3.76±0.83分)均无差异(P>0.05)。术后7、30d,研究组OSDI评分(42.12±10.54、48.71±9.74分)和FL评分(5.10±1.12、4.55±1.04分)显著低于对照组,研究组BUT(3.29±0.54、3.56±0.45s)与SⅠt(5.62±0.91、5.21±0.73mm/5min)均显著高于对照组(P<0.05)。结论:超声乳化联合人工晶状体植入术前应用人工泪液可明显改善术后早期干眼症状,恢复泪膜功能,防止术后干眼症加重。

Influence of preoperative application of artificial tears on ocular surface of cataract patients with xerophthalmia

·AIM:To investigate the influence of preoperative application artificial tears on tear film function and dry eye in cataract patients with dry eye after phacoemulsification and intraocular lens implantation.·METHODS:Between June 2018 to June 2019,107 patients were diagnosed cataract with dry eye before phacoemulsification and intraocular lens implantation in our hospital.These patients were randomly divided into control groups(not treated artificial tears preoperative)and study group(treated with 0.1%sodium hyaluronate eye drops at 1wk preoperative).Ocular surface disease index(OSDI)questionnaire,break up time(BUT),SchirmerⅠtest(SⅠt)and fluorescein stain test(FL)were observed and analyzed at preoperatively and 7,30d postoperatively.·RESULTS:There were no significant differences in preoperative OSDI scores(28.59±8.10 vs 29.08±9.18),BUT(5.15±0.47 vs 5.02±0.53s),SⅠt(6.86±0.98 vs 6.71±1.02mm/5min),and FL scores(3.96±0.89 vs 3.76±0.83)between the two groups(P>0.05).At 7 and 30d postoperative,the OSDI score and FL score of the study group were significantly lower than the control group,and the BUT and SⅠt of the study group were significantly higher than the control group(P<0.05).·CONCLUSION:Application of artificial tears before phacoemulsification combined with intraocular lens implantation can significantly relieve early dry eye symptoms,restore tear film function,and prevent postoperative dry eye aggravation.