动态血压24h监测观察厄贝沙坦降压效果

目的　采用动态血压监测仪观察厄贝沙坦治疗高血压病的疗效。方法　高血压病患者 4 4例 ,厄贝沙坦 75～ 15 0mg ,最大量 30 0mg ,每日 1次口服 ,共用 4周 ,动态血压监测仪监测血压。结果　治疗前后 2 4h平均血压、夜晚和白昼的平均血压及血压负荷值自身对照有显著差别 (P <0 .0 1)。降低收缩压和舒张压的谷 /峰比值分别为 0 .6 5± 0 .2 3和 0 .70± 0 .2 4。结论　厄贝沙坦降压效果确切 ,服用方便 ,每日 1次可在 2 4h内稳定控制血压。有较好的谷 /峰比值 ,是一种理想的降压药物

Effect of Irbesartan on hypertension by 24-hour ambulatory blood pressure monitoring

Objective To evaluate the efficacy of irbesartan on hypertension by 24-hour ambulatory blood pressure monitoring. Methods Forty-four patients with hypertension received Irbesartan(the dosage of 75) once orally per day, for four weeks.The doses were maintained or increased to 150-mg after one week based on the blood pressure variation, and it might be increased to 300-mg next week. 24-hour ambulatory blood pressure was monitored before and after the treatment. The total course lasted for 4 weeks.Results The average pressure during 24 hours per day decreased obviously(P<0.01).The trough/peak of the systolic blood pressure and the diastolic blood pressure were 0.65±0.23 and 0.70±0.24 respectively.Conclusion Irbesartan is obviously effective and taken easily for patients with hypertension .Administration once per day will keep long and stable efficiency .It is a good medicine in treating hypertension for better trough/peak.