| 模拟舱室内肢体爆炸伤后肺损伤的特点及短暂全身低温对肺损伤程度的影响 |
| |
| 引用本文： | 甯交琳,赖西南,莫立稳,梁杰,王丽丽.模拟舱室内肢体爆炸伤后肺损伤的特点及短暂全身低温对肺损伤程度的影响[J].创伤外科杂志,2008,10(3):271-273. |
| |
| 作者姓名： | 甯交琳 赖西南 莫立稳 梁杰 王丽丽 |
| |
| 作者单位： | 第三军医大学大坪医院野战外科研究所六室,创伤、烧伤与复合伤国家重点实验室,重庆,400042 |
| |
| 摘 要： | 目的 观察密闭舱室环境下,肢体爆炸伤后肺损伤的特点及全身短暂低温对肺损伤程度的影响.方法 24只雄性SD大鼠,随机分为对照组、单纯致伤组和短暂全身低温干预组.采用比色法测定肺组织丙二醛(MDA)含量,超氧化物岐化酶(SOD)和髓过氧化物酶(MPO)活性;肺湿重/干重代表总肺水含量;观察肺组织病理改变.结果 密闭环境中,肢体爆炸伤后肺组织发生出血、水肿,肺间隔断裂,炎症细胞浸润,肺组织MDA含量和MPO活性明显升高,SOD活性明显下降;短暂全身低温可减轻肺组织出血、水肿和炎症细胞的浸润,降低肺组织MDA含量和MPO活性,增加SOD活性.结论 密闭环境中,肢体爆炸伤后发生明显的肺冲击伤,氧化应激和炎症细胞浸润可进一步加重肺组织损伤,短暂全身低温可通过减轻氧化应激和炎症细胞浸润,减轻肺组织损伤.
|
| 关 键 词： | 低温 舱室 肢体损伤 爆炸伤 肺损伤 模拟 舱室 肢体 爆炸 伤后 肺损伤 低温 损伤程度 影响 closed explosive injury limb lung injury hypothermia transient 肺组织损伤 氧化应激 肺冲击伤 组织发生 炎症细胞浸润 |
| 文章编号： | 1009-4237(2008)03-0271-03 |
| 修稿时间： | 2008年1月9日 |
Effects of transient whole-body hypothermia on lung injury after limb explosive injury in closed cabin |
| |
| NING Jiao-lin,LAI Xi-nan,MO li-wen,et al..Effects of transient whole-body hypothermia on lung injury after limb explosive injury in closed cabin[J].Journal of Traumatic Surgery,2008,10(3):271-273. |
| |
| Authors: | NING Jiao-lin LAI Xi-nan MO li-wen |
| |
| Institution: | NING Jiao-lin,LAI Xi-nan,MO li-wen,et al.(State Key Laboratory of Trauma,Burns , Combined Injury,Institute of Surgery Research,Department 6,Daping Hosptial,Third Military Medical University,Chongqing 400042,China) |
| |
| Abstract: | Objective To study the characteristic of lung injury after explosive injuries of limb in closed canbin and effects of transient whole-body hypothermia on severity of lung injury.Methods Twenty-four healthy male SD rats were randomly divided into control group,simple explosive injury group and transient whole-body hypothermia group.Malondialdehyde(MDA)content,superoxide dismutase(SOD) and myeloperoxidase(MPO) activity of lung tissue were assayed with chromatometry.Lung water content was represented by lung w... |
| |
| Keywords: | hypothermia cabin injury of limb explosive injury lung injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
