| 拉米夫定治疗慢性乙型肝炎肝硬化临床观察94例 |
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| 引用本文： | 周晓斌. 拉米夫定治疗慢性乙型肝炎肝硬化临床观察94例[J]. 中国医药导报, 2010, 7(23) |
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| 作者姓名： | 周晓斌 |
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| 作者单位： | 广西壮族自治区桂林市南溪山医院肝病科,广西桂林,541002 |
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| 摘 要： | 目的:探讨拉米夫定治疗慢性乙型肝炎肝硬化患者的疗效。方法:选择慢性乙型肝炎肝硬化患者94例,随机分为治疗组和对照组,两组均采用常规对症治疗,治疗组加服拉米夫定100mg,1次/d,疗程均为12个月。结果:治疗组肝功能指标总胆红素和谷丙转氨酶(ALT)及肝纤维化指标透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)明显好转,表明拉米夫定有利于改善肝功能和肝纤维化。27例经12个月拉米夫定治疗后,HBVDNA定量明显下降,实验组HBeAg转阴率为51.06%,对照组HBeAg转阴率为6.38%,治疗组HBeAg转阴率显著高于对照组,表明拉米夫定对治疗慢性乙型肝炎肝硬化有显著的疗效。结论:拉米夫定有抑制肝组织纤维化、改善肝功能、改善预后的良好效果,且不良反应少,是治疗乙型肝炎肝硬化较为合适的药物。
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| 关 键 词： | 拉米夫定 慢性乙型肝炎肝硬化 治疗 |
Clinical observation of Lamivudine for chronic hepatitis B cirrhosis in 94 cases |
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| ZHOU Xiaobin. Clinical observation of Lamivudine for chronic hepatitis B cirrhosis in 94 cases[J]. China Medical Herald, 2010, 7(23) |
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| Authors: | ZHOU Xiaobin |
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| Affiliation: | ZHOU Xiaobin (Hepatology Department; Nanxishan Hospital of Guilin City; Guangxi Zhuang Autonomus Region; Guilin 541002; China); |
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| Abstract: | Objective:To evaluate the therapeutic effect of Lamivudine in the treatment of chronic hepatitis B cirrhosis patients.Methods:94 patients with chronic hepatitis B cirrhosis were selected and divided into treatment group and con trol group randomly,both groups were treated with conventional therapy,the treatment group took 100 mg Lamivudine once per day.12 months was named as a course.Results:For treatment group,liver function s outcomes of total bilirubin and ALT liver fibrosis HA,PCⅢ,CⅣ were much improved ... |
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| Keywords: | Lamivudine Chronic hepatitis B cirrhosis Treatment |
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