Neurotoxicity of quinolinate in the rat nucleus basilis magnocellularis |
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| Authors: | R.J. Boegman R. Metcalf R.J. Riopelle S.K. Ludwin |
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| Affiliation: | Department of Pharmacology and Toxicology, Queen's University, Kingston, Ont., Canada. |
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| Abstract: | Injections of quinolinic acid (QUIN) alone or combinations of QUIN with dipicolinic acid, Mg2+ or 3,4-diaminopyridine were made into the nucleus basalis magnocellularis of the rat. Choline acetyltransferase activity in the cortex decreased following injections of QUIN and this was antagonized by co-injections of QUIN with dipicolinic acid or Mg2+. Co-injections of QUIN with 3,4-diaminopyridine increased the neurotoxicity of quinolinic acid, while diaminopyridine alone was not toxic. |
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| Keywords: | Excitotoxin Nucleus basalis Choline acetyltransferase Neurotoxicity Quinolinic acid |
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