幽门螺杆菌和维生素C与胃黏膜病变关系的研究

目的 研究Hp感染和胃液中维生素C浓度与胃黏膜病变的关系,探讨Hp致病、致癌机制.方法 用高铁还原法测定胃液中维生素C浓度,用快速尿素酶试验、病理Giemsa染色和细菌培养检测Hp.对部分Hp阳性的胃部良性病变患者进行Hp根除治疗,并比较治疗前后胃液中维生素C浓度的变化.结果 Hp阳性各胃部病变组患者胃液中维生素C浓度分别为:慢性浅表性胃炎组(18.3±4.5)mg/L、萎缩性胃炎伴肠上皮化生组(9.1±3.3)mg/L、异型增生组(8.2±2.7)mg/L、胃癌组(5.2±1.6)mg/L,与对照组[(35.2±7.2)mg/L]比较差异均有统计学意义(P＜0.05);经Hp根除治疗后,Hp根除患者胃液中维生素C浓度恢复正常,而Hp未根除患者其胃液中维生素C浓度治疗前后无明显变化.结论 Hp感染可导致胃液中维生素C浓度降低,这可能是Hp致病、致癌机制之一;根除Hp可以恢复胃液中维生素C浓度,这有利于预防胃癌的发生.

A study on the relationship of helicobacter pylori and vitamin C to gastric mucosa lesions

Objective To study the relationship of Hp infection and gastric juice vitamin C concentration to gastric mucosa lesions,as well as its mechanisms of pathogenesis and carcinogenesis.Methods Vitamin C concentration in gastric juice was measured by using reduced ferric method.Hp was determined by fast urease test,pathologic Giemsa stain and bacterial culture.Hp eradication treatment was performed on part of Hp positive patients,and the vitamin C concentration in gastric juice before and after Hp eradication was compared. Results Gastric juice vitamin C concentrations in each Hp positive test groups were:(18.3±4.5)mg/L(chronic superficial gastritis group),(9.1±3.3)mg/L(atrophic gastritis with intestinal metaplasia group),(8.2±2.7)mg/L(dysplasia group),and (5.2±1.6)mg/L(gastric cancer group) respectively,which were significantly lower than that in control group [(35.2±7.2)mg/L],P＜0.05.After eradication of Hp,the vitamin C concentrations in gastric juice returned to normal,whereas it had no significant difference in those with failure of Hp eradication.Conclusions Hp infection may cause a significant lowering of gastric juice vitamin C concentration,which may be one of the mechanisms of its pathogenesis and carcinogenesis.Eradication of Hp can return the vitamin C concentration in gastric juice to normal,which may contribute to guard against the occurrence of gastric cancer.