桂枝汤的药理学研究——六、对免疫功能的双向调节作用

以8.75～35.0g/kg/天剂量的桂枝汤口饲动物,对正常小鼠的血清溶血素(Ⅰ)、血清凝集素(Ⅱ)水平和ANAE( )淋巴细胞比率(Ⅲ)均无明显影响。小鼠感染流感病毒4天后,Ⅰ、Ⅱ的水平和Ⅲ的比率比正常动物均显著降低;给予上述剂量的桂枝汤,则均能显著提高Ⅰ、Ⅱ、Ⅲ,使之达到正常水平。给小鼠左旋咪唑25mg/kg,均可使Ⅰ、Ⅱ、Ⅲ显著提高;给予桂枝汤,又均能使之下降,恢复到正常水平。实验结果表明,桂枝汤不影响正常小鼠的循环抗体水平和T、B淋巴细胞比率,但对偏亢或受抑的动物,有调节使之正常化的作用。

Pharmacological Study on the Decoction of Cinnamon Twigs VI Bidirectional Regulatic Action of the Decoction on the Immunological Function

Serum level of hemolysin ( I ) or agglutinin ( II) and ratio of ANAE( ) -lymphocyte (I) in blood were not disturbed when 8.75-35.0 g crude drugs/kg/day p.o. of the Decoction of Cinnamon Twigs (DCT) was administrated in normalmice. I, I and I were decreased significantly in mice infected with influenza virus in4 days, administration of DCT in the same dosages eould increased those parameters tothe normal level in infected mice. On the other hand, 25mg/kg of levamisole could increased the Ievel of I, II and III ,the administration of DCT also decreased thoseindexes to the normal. The result indicated that the action of bidirectional regulationand normalization with the DCT were found in defferent (hypo or hyper) conditions ofimmunological function, but DCT was not interfered normal situation in mice.