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Immunohistochemical evidence of vasoactive intestinal polypeptide-containing neurons and nerve fibers in sympathetic ganglia
Authors:T. Hökfelt  L.-G. Elfvin  M. Schultzberg  K. Fuxe  S.I. Said  V. Mutt  M. Goldstein
Affiliation:1. Departments of Histology, Anatomy and Biochemistry, Karolinska Institutet, Stockholm, Sweden;2. Departments of Internal Medicine and Pharmacology, University of Texas, Health Science Center, Dallas, Texas, U.S.A.;3. Department of Psychiatry, New York University Medical Center, New York, U.S.A.
Abstract:Neurons and nerve fiber networks showing immunoreactivity for vasoactive intestinal polypeptide have been observed in some sympathetic ganglia with the help of the indirect immunofluorescence technique. Antisera to tyrosine hydroxylase and dopamine β-hydroxylase were used to identify catecholamine cells on consecutive sections. In the coeliac-superior mesenteric ganglion complex and the inferior mesenteric ganglion of the guinea-pig very dense networks of vasoactive intestinal polypeptide-positive varicose nerve fibers were observed around the principal ganglion cells. Only very few immunofluorescent fibers were seen in relation to the small intensely fluorescent cells. Occasionally some immunoreactive principal ganglion cells were found. In the same ganglia of the rat a considerably less dense network of vasoactive intestinal polypeptide-positive nerve fibers was present. The superior cervical ganglia of both species contained only a few vasoactive intestinal polypeptide-immunofluorescent fibers and no positively reacting cells were found.
Keywords:DBH  dopamine β-hydroxylase  FITC  fluorescein isothiocyanate  SIF  small intensely fluorescent  TH  tyrosine hydroxylase  VIP  vasoactive intestinal polypeptide
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