Unbalanced estrogen metabolism in thyroid cancer |
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| Authors: | Muhammad Zahid Whitney Goldner Cheryl L Beseler Eleanor G Rogan Ercole L Cavalieri |
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| Institution: | 1. Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, , Omaha, NE;2. Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, , Omaha, NE;3. Department of Psychology, Colorado State University, , Fort Collins, CO;4. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, , Omaha, NE |
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| Abstract: | Well‐differentiated thyroid cancer most frequently occurs in premenopausal women. Greater exposure to estrogens may be a risk factor for thyroid cancer. To investigate the role of estrogens in thyroid cancer, a spot urine sample was obtained from 40 women with thyroid cancer and 40 age‐matched controls. Thirty‐eight estrogen metabolites, conjugates and DNA adducts were analyzed by using ultraperformance liquid chromatography/tandem mass spectrometry and the ratio of adducts to metabolites and conjugates was calculated for each sample. The ratio of depurinating estrogen‐DNA adducts to estrogen metabolites and conjugates significantly differed between cases and controls (p < 0.0001), demonstrating high specificity and sensitivity. These findings indicate that estrogen metabolism is unbalanced in thyroid cancer and suggest that formation of estrogen‐DNA adducts might play a role in the initiation of thyroid cancer. |
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| Keywords: | thyroid cancer estrogen‐DNA adducts unbalanced estrogen metabolism |
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