Importance of Detecting Multidrug Resistance Proteins in Acute Leukemia Prognosis and Therapy |
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| Authors: | Ana Carolina Rabello de Moraes Caroline Klein Maranho Gabriela Schneider Rauber Maria Cláudia Santos‐Silva |
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| Institution: | 1. Programa de Pós‐gradua??o em Farmácia, Universidade Federal de Santa Catarina, Campus Trindade, , Florianópolis – SC, Brazil;2. Departamento de Análises Clínicas, Universidade Federal de Santa Catarina, Campus Trindade, , Florianópolis – SC, Brazil |
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| Abstract: | Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment. J. Clin. Lab. Anal. 27:62–71, 2013. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | multidrug resistance ABCB1 ABCC1 LRP acute leukemia |
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