Acute effects of single‐dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brain |
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Authors: | Rowena Handley Fernando O. Zelaya A.A.T. Simone Reinders Tiago Reis Marques Mitul A. Mehta Ruth O'Gorman David C. Alsop Heather Taylor Atholl Johnston Steve Williams Philip McGuire Carmine M. Pariante Shitij Kapur Paola Dazzan |
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Affiliation: | 1. Department of Psychosis Studies, King's College London, Institute of Psychiatry, United Kingdom;2. Department of Neuroimaging, King's College London, Institute of Psychiatry, United Kingdom;3. Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;4. BCN Neuroimaging Center, University of Groningen, Groningen, The Netherlands;5. University Children's Hospital, Zurich, Switzerland;6. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA;7. Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom;8. Department of Psychological Medicine, Perinatal Psychiatry & Stress, King's College London, Institute of Psychiatry, United Kingdom;9. NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust, London, United Kingdom |
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Abstract: | Antipsychotic drugs act on the dopaminergic system (first‐generation antipsychotics, FGA), but some also directly affect serotonergic function (second‐generation antipsychotics, SGA) in the brain. Short and long‐term effects of these drugs on brain physiology remain poorly understood. Moreover, it remains unclear whether any physiological effect in the brain may be different for FGAs and SGAs. Immediate (+3.30 h) and different effects of single‐dose FGA (haloperidol, 3 mg) and a SGA (aripiprazole, 10 mg) on resting cerebral blood flow (rCBF) were explored in the same 20 healthy volunteers using a pulsed continuous arterial spin labeling (pCASL) sequence (1.5T) in a placebo‐controlled, repeated measures design. Both antipsychotics increased striatal rCBF but the effect was greater after haloperidol. Both decreased frontal rCBF, and opposite effects of the drugs were observed in the temporal cortex (haloperidol decreased, aripiprazole increased rCBF) and in the posterior cingulate (haloperidol increased, aripiprazole decreased rCBF). Further increases were evident in the insula, hippocampus, and anterior cingulate after both antipsychotics, in the motor cortex following haloperidol and in the occipital lobe the claustrum and the cerebellum after aripiprazole. Further decreases were observed in the parietal and occipital cortices after aripiprazole. This study suggests that early and different rCBF changes are evident following a single‐dose of FGA and SGA. The effects occur in healthy volunteers, thus may be independent from any underlying pathology, and in the same regions identified as structurally and functionally altered in schizophrenia, suggesting a possible relationship between antipsychotic‐induced rCBF changes and brain alterations in schizophrenia. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc. |
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Keywords: | arterial spin labeling resting blood flow antipsychotics haloperidol aripiprazole |
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