Haplotype Kernel Association Test as a Powerful Method to Identify Chromosomal Regions Harboring Uncommon Causal Variants |
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Authors: | Wan‐Yu Lin Nengjun Yi Xiang‐Yang Lou Degui Zhi Kui Zhang Guimin Gao Hemant K Tiwari Nianjun Liu |
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Institution: | 1. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, , Taipei, Taiwan;2. Department of Biostatistics, University of Alabama at Birmingham, , Birmingham, Alabama;3. Department of Biostatistics, Virginia Commonwealth University, , Richmond, Virginia |
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Abstract: | For most complex diseases, the fraction of heritability that can be explained by the variants discovered from genome‐wide association studies is minor. Although the so‐called “rare variants” (minor allele frequency MAF] < 1%) have attracted increasing attention, they are unlikely to account for much of the “missing heritability” because very few people may carry these rare variants. The genetic variants that are likely to fill in the “missing heritability” include uncommon causal variants (MAF < 5%), which are generally untyped in association studies using tagging single‐nucleotide polymorphisms (SNPs) or commercial SNP arrays. Developing powerful statistical methods can help to identify chromosomal regions harboring uncommon causal variants, while bypassing the genome‐wide or exome‐wide next‐generation sequencing. In this work, we propose a haplotype kernel association test (HKAT) that is equivalent to testing the variance component of random effects for distinct haplotypes. With an appropriate weighting scheme given to haplotypes, we can further enhance the ability of HKAT to detect uncommon causal variants. With scenarios simulated according to the population genetics theory, HKAT is shown to be a powerful method for detecting chromosomal regions harboring uncommon causal variants. |
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Keywords: | similarity linkage disequilibrium rare variants JAK2 gene body‐mass index |
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