RETRACTED ARTICLE: Undertreatment of breast cancer in the elderly |
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Authors: | Nicola Rocco Corrado Rispoli Gennaro Pagano Silvio Ascione Rita Compagna Michele Danzi Antonello Accurso Bruno Amato |
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Affiliation: | 1.Department of Biomedical, Surgical and Dental Sciences,University of Milan,Milan,Italy;2.Department of General Surgery,Cardinale Ascalesi Hospital - ASL NA1,Naples,Italy;3.Department of Translational Medical Sciences,University “Federico II” of Naples,Naples,Italy;4.Private Practice, Palazzo Donn’Anna,Naples,Italy;5.Department of General, Geriatric, Oncologic Surgery and Advanced Technologies,University “Federico II” of Naples,Naples,Italy |
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Abstract: | AimsThe effect of undertreatment with adjuvant hormonal therapy, chemotherapy or radiation was studied in elderly women with breast cancer.MethodsA prospectively maintained database was used to identify women undergoing potentially curative surgery between 1997 and 2011. The presentation, pathologic findings, treatment and outcomes of 449 women over 65 were compared to the findings in 1049 younger patients. Moreover, conventionally treated and undertreated elderly patients were identified and their characteristics and outcomes were compared.ResultsBoth young and old patients presented most frequently with mammographic findings, but older patients presented more frequently with mammographic masses while younger patients presented more frequently with mammographic calcifications. Cancers of older patients were signicantly more favorable than cancers in younger patients with more infiltrating lobular, fewer ductal carcinoma in situ and more frequently estrogen receptor positive and fewer were poorly differentiated. Elderly patients had less axillary surgery, less adjuvant radiation therapy and more hormonal therapy. Fourty-six percent of the 449 elderly patients were undertreated by conventional criteria. Undertreated patients were more frequently in situ, better differentiated, smaller, and more often estrogen receptor positive. Forty-four percent of the undertreated patients died during follow-up without disease recurrence.ConclusionsDespite undertreatment, local and distant disease-free survival was comparable to patients who were not undertreated. |
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