肝素缓释系统抑制兔眼白内障术后后发性白内障的实验研究

目的 通过观察肝素缓释系统植入兔眼白内障超声乳化术后的角膜、前房、后囊膜的浑浊分级及其病理变化情况,探讨其对后发性白内障的抑制作用.方法 健康新西兰大白兔24只共48眼,随机分为4组,建立白内障动物模型,在行白内障超声乳化术后分别囊袋内注入200U/ml肝素0.1ml（第1组）,后房内植入空白缓释剂（第2组）,后房内植入肝素缓释系统（第3组）及生理盐水滴眼（对照组）.术后不同时间应用裂隙灯显微镜观察角膜、前房及晶状体后囊膜等眼部组织的变化,光镜观察后囊膜组织病理学改变.结果 肝素缓释剂组前房反应小,后囊膜混浊程度及发生时间与其他三组的后囊膜混浊率有显著性差异（P〈0.05）.结论 肝素缓释剂能有效地抑制兔眼白内障术后后发性白内障的发生.

An experimental study on the prevention of posterior capsular opacification by using heparin drug deliver system in rabbit eyes

Objective To investigate the preventive effect of heparin drug deliver system on posterior capsulur opacification（PCO）in rabbit eyes. Methods Twenty-four New Zealand albino rabbits （48 eyes） undergoing phacoemulsification were equally divided into four groups： heparin （200U/ml） implanted into the posterior chamber （group 1）,a cartier drug deliver system implanted into the posterior chamber （group 2）; heparin drug deliver system implanted into the posterior chamber （group 3） and receiving normal saline eye drops （control group）. All the comea, anterior chamber reaction and lens posterior eapsula of the 48 eyes were examined by slit-lamp microscopy and optical microscopy. Results A significant difference was found in the rate and degree of posterior capsulur opacifieation between heparin drug deliver system group and others （P〈0.05）. Conclusion Heparin deliver system can effectively prevent the occurrence of PCO after cataract.