奥扎格雷钠联合阿司匹林治疗急性脑梗死临床研究

目的 研究奥扎格雷钠与阿司匹林联合治疗急性脑梗死的疗效.方法 将227例急性脑梗死患者采用数字随机方法分为联合用药组(90例),奥扎格雷钠组(55例),阿司匹林组(35例),对照组(47例).联合用药组静脉滴注奥扎格雷纳80 mg,每12小时1次,口服阿司匹林肠溶片100 mg/d；奥扎格雷钠组给予奥扎格雷钠80 mg静脉滴注,每12小时1次；阿司匹林组口服阿司匹林肠溶片100 mg/d；对照组依据病情只应用常规药物治疗,如脱水降颅压、改善脑循环、改善脑细胞代谢等.各组疗程均为14 d,比较4组患者的总有效率,以及各组患者中男性患者与女性患者的有效率.结果 联合用药组基本治愈20例,显著进步43例,进步21例,总有效率93.3％ (84/90)；奥扎格雷钠组分别为7、20、18例,总有效率81.8％ (45/55)；阿司匹林组分别为3、10、11例,总有效率68.6％(24/35)；对照组分别为3、2、13例,总有效率38.3％(18/47).联合用药组总有效率高于其他3组,奥扎格雷钠组总有效率明显高于阿司匹林组和对照组(均P＜0.05).联合用药组男性患者总有效率为91.8％(45例),女性患者总有效率为95.1％(39例)；奥扎格雷钠组分别为83.3％(25例)、80.0％(20例)；阿司匹林组分别为70.0％(14例)、66.7％(10例)；对照组分别为37.3％(10例)、40.0％(8例).4组组内不同性别间总有效率比较,差异均无统计学意义(均P＞0.05).结论 奥扎格雷钠与阿司匹林联合治疗急性脑梗死明显改善临床预后,总有效率优于单用奥扎格雷钠和单用阿司匹林.

The clinical effect of combination therapy with sodium ozagrel and aspirin for acute cerebral infarction

Objective To observe the effects of ozagrel and aspirin treating acute cerebral infarction （ACI）. Methods Two hundred and twenty-seven patients with acute cerebral infarction patients were divided into combined treatment group （90 cases） ： the sodium ozagrel group （55 cases）, the aspirin group （35 cases） and control group （47 cases）. The combined treatment group was given the sodium ozagrel 80 mg every 12 hours and oral aspirin enteric-coated tablets 100 mg/d; sodium ozagrel group was given the sodium ozagrel 80 mg intravenous infusion. Aspirin group was given aspirin enteric-coated tablets 100 mg. The control group was given conventional drug therapy based on condition. The time of therapy of each group was 14 days. The clinical neurologic impairment score was evaluated to show the therapeutic effect of each group. Results Total effective rate of combined treatment group was 93.3% （84/90） ; sodium ozagrel group was 81.8% （ 45/55 ） ; aspirin group was 68.6% （ 24/35 ） and control group was 38.3% （18/47）. The total effective rate of combined treatment was significantly higher than that of other groups （ P 〈 0.05 ）. Conclusion The combination therapy with ozagrel and aspirin for acute cerebral infarction is effective.