CD147、OPN和MMP-2在口腔鳞状细胞癌中的表达及意义

目的研究口腔鳞状细胞癌(OSCC)中基质金属蛋白酶诱导因子(CD147)、骨桥蛋白(OPN)和基质金属蛋白酶-2(MMP-2)的表达和意义。方法采用免疫组化SP法对35例OSCC组织中CD147、OPN和MMP-2的表达进行检测,并分析这3个指标间的相关性。结果 CD147、OPN和MMP-2在OSCC组织中高表达,阳性表达率分别为65.71%、71.43%、68.57%;三者的表达均与OSCC病理分级、临床分期和淋巴结转移有关(P<0.05),而与性别、年龄、生长部位无明显相关性(P>0.05);随着病理分级的降低、临床分期的增高和淋巴结转移,三者的阳性表达率均升高;三者之间的表达互呈正相关(MMP-2和CD147,r=0.653;MMP-2和OPN,r=0.540;CD147和OPN,r=0.381;P均<0.05)。结论 CD147、OPN和MMP-2的表达与OSCC的病理分级及侵袭转移密切相关。

Expressions and Significances of CD147,OPN and MMP-2 in Oral Squamous Cell Carcinoma

Objective To evaluate the expressions and significances of CD147,OPN and MMP-2 in oral squamous cell carcinoma(OSCC).Methods The expressions of CD147,OPN and MMP-2 were detected by immunohistochemical method(SP) in 35 cases of OSCC.The relationships between the expressions of CD147,OPN and MMP-2 and clinic histopathologic parameters of OSCC were analyzed.Results The expression rates of CD147,OPN and MMP-2 in OSCC tissues were 65.71%,71.43% and 68.57% respectively.The expressions of CD147,OPN and MMP-2 were positively correlated with tumor histopathologic type,clinical stage and lymph node metastasis(P<0.05),but not correlated with age,gender and the location of tumor(P>0.05).The positive correlations were found among the expressions of CD147,OPN and MMP-2(MMP-2 and CD147,r=0.653;MMP-2 and OPN,r=0.540;CD147 and OPN,r=0.381;P<0.05).Conclusion The expressions of CD147,OPN and MMP-2 increase in OSCC and may be the potential predictor of the malignant degree of OSCC.