原发性高血压患者血清维生素D水平及相关性研究

目的 了解原发性高血压患者血清维生素D的变化,并探讨维生素D对原发性高血压发展的影响.方法 按危险因素将140例原发性高血压患者分为低危组(1级高血压且无其他危险因素,56例)、中危组(2级高血压或1级高血压伴1～2个危险因素,53例)和高危组(3级高血压或1～2级高血压伴≥3个危险因素或任何一级高血压伴1项靶器官损害或1种临床疾患,31例),并设立对照组(体检健康者,33例),检测4组的血清钙、磷、25-羟基维生素D325(OH)D3]、甲状旁腺激素(PTH).结果 低危、中危、高危组25(OH)D3分别为(27±6)、(27±5)、(21±5)μg/L,对照组为(32±8)μg/L,低危组与中危组之间差异无统计学意义(P＞0.05),其余各组之间差异有统计学意义(P＜0.05).25(OH)D3与收缩压、舒张压存在负相关(r值分别为-0.412、-0.377,均P＜0.01),与PTH、钙、磷、年龄无明显相关性.结论 原发性高血压患者血清维生素D水平降低,尤其是伴有高危因素的患者血清维生素D水平降低更明显.

Association between primary hypertension and serum vitamin D levels

Objective To investigate the changes of serum vitamin D levels in primary hypertension pa- tients. Methods According to risk factors, 56 patients were selected as low risk group; 53 patients were selected as intermediate risk group; 31 patients were selected as high risk group and 33 healthy subjects were selected as nor- real control group. The 25-hydroxyvitamin D3 was measured with enzyme-linked immunoassay（ELISA）. The statisti- cal data was analyzed by SPSS 18. 0 software. Results The sex and age of four groups objects were not significantly different. The 25 （OH）D3 of low risk group was （27 ± 6 ） μg/L; the 25 （OH） D3 of intermediate risk group was （ 27 ± 5 ） μg/L. The 25 （OH） D3 of high risk group was （ 21± 5 ） μg/L. The 25 （OH） D3 of the healthy subjects was （32 ＋ 8）Ixg/L. The 25（OH） D3 of low risk and high risk and the healthy groups objects were significantly different （P 〈 0. 05）. With simple regression analysis, the 25 （OH） D3 was positively associated with systolic pressure and diastolic pressure （r = -0. 412, -0. 377, all P 〈 0. 01 ） , but not significantly associated with the parathyroid hor- mone, calcium, phosphorous and age. Conclusion There is a high level of hypovitaminosis D in primary hyperten- sion patients.