银杏叶提取物治疗早期股骨头缺血性坏死的疗效观察

目的 观察经导管灌注银杏叶提取物治疗早期股骨头缺血性坏死(ANFH)的疗效,探讨其作用机制.方法 选择ANFH病例74例,完全随机分为治疗组(43例)和对照组(31例).治疗组给予银杏叶提取物注射液40ml,对照组予以丹参注射液40ml,分别加入右旋糖酐150 ml、罂粟碱30 mg、尿激酶30万U、山莨菪碱20 mg,混合液灌注股骨头滋养血管,比较2组患者的疗效及治疗前后的滋养血管、骨质的影像学改变.结果 治疗组43例中痊愈13例、显效19例、有效11例,总有效率100.0％；对照组31例中痊愈6例、显效9例、有效13例,总有效率90.3％；治疗组总有效率明显高于对照组,差异有统计学意义(P＜0.05).结论 经导管灌注银杏叶提取物治疗ANFH安全有效,值得临床推广.

Clinical thereapeutic effect of extract of Ginkgo biloba extract on interventional therapy for early avascular necrosis of the femoral head

Objective To observe the clinical efficacy of Ginkgo biloba extract （GBE） with transeatheter treatment for early avascular necrosis of the femoral head （ANFH） and to investigate the mechanism. Methods The patients with early ANFH （n =74） were randomly divided into the treatment group（n =43 ） treated with GBE injection and control group（ n = 31 ） treated with Danshen injection. Papaverine, urokinase ,654-2 and low molecular weight dextran were injected directly into the arteries supplying the femoral head. The clinical data, including clinical symptoms, angiography and the change of bone was collected for evaluating the efficacy of treatment. Results Compared with the treatment group, no significant difference in the angiography of arteries of the femoral heads and short term efficacy was found in the control group（P 〉0. 05） after interventional therapy. However, the improvement of bone in the images and long term efficacy were recorded in the treatment group（ P 〈 0. 05 ） after the treatment. Conclusion Transeatheter intra-arterial infusion with GBE is safe and effective for the treatment of early ANFH.