肿瘤患者与健康对照人群半胱氨酸蛋白酶抑制剂C水平的比较研究

目的探讨血清半胱氨酸蛋白酶抑制剂C(cystatin C)浓度水平与肿瘤的关系。方法颗粒增强免疫比浊法测定273例实体恶性肿瘤患者(肿瘤组)和185例健康体检者(对照组)的血清cystatin C浓度,比较两组血清cystatin C浓度水平的差异并分析其影响因素。结果肿瘤组、对照组cystatin C水平差异无统计学意义(P=0.075);但去除混杂因素年龄的影响后两者差异有统计学意义(P<0.01);且多元回归分析显示cystatin C水平对照组比肿瘤组高、男性比女性高,且随年龄增长、肾小球滤过率(eGFR)水平下降而升高。结论 Cystatin C可能在肿瘤的发生发展中起到一定作用。

The Levels of Serum Cystatin C in Patients with Tumors and Healthy Controls

Objective To determine the association between serum cystatin C and tumors.Methods Serum samples were obtained from 273 patients with tumors and 185 healthy volunteers.Serum cystatin C was determined by particle-enhanced turbidimetric immunoassay(PETIA).Student t-test,covariance analysis and multiple linear regressions were performed to examine the differences in the levels of cystatin C between the two groups.Results The student t-test did not show significant statistical differences in the serum cystatin C levels between the two groups(P=0.075).However,such differences became statistically significant(P<0.01) after adjustment of age.The multiple liner regression demonstrated that healthy volunteers and men had higher levels of cystatin C than those with tumors and women.Cystatin C also increased with age and decreases with estimating glomerular filtration rate.Conclusion Cystatin C may be associated with the genesis and development of tumors.