大环内酯类抗生素佐治毛细支气管炎临床分析

目的：观察以红霉素为代表的大环内酯类抗生素治疗毛细支气管炎的疗效及平喘作用。方法：全部患者选自2010年1月～2011年1月在本院住院的50例毛细支气管炎的患儿,年龄2个月～2岁。观察组男15例,女10例,对照组男14例,女11例。两组均给予氧疗、利巴韦林雾化吸入,及抗病毒常规治疗,观察组在此基础上加用红霉素30mg/（kg·d）分3次口服,疗程7～14d,平均用药8d观察疗效。结果：观察组总有效率为96%（24/25）,临床显效占56%（14/25）,对照组总有效率为88%（22/25）,临床显效占32%（8/25）,观察组明显优于对照组（P〈0.05）。观察组喘憋的发生率为16%,明显低于对照组的52%。结论：随着红霉素的平喘作用已逐渐被发现,临床上毛细支气管炎患儿益早期应用以红霉素为主的大环内酯类抗生素。

Clinical analysis of the treatment of bronchiolitis with macrolide antibiotics

Objective：To observe the therapeutic and antiasthmatic effect of macrolide antibiotics,erythromycin in this study,on bronchiolitis.Methods：50 children treated in the author＇s hospital from January 2010 to January 2011 for bronchiolitis were chosen.The children aged from 2 months to 2 years old.There were 15 males and 10 females in the observation group and 14 males and 11 females in the control group.All the patients were given oxygen therapy,ribavirin inhalation,and conventional anti-viral treatment.In addition to that,patients in the observation group were given oral administration of erythromycin 30 mg/（kg·d） 3 times a day.The course of treatment was 7-14 days,and the therapeutic effect was observed,on average,8 days after drug use.Results：The total effective rate in the treatment group was 96%（24/25）,and clinical effective rate was 56%（14/25）;the control group were 88%（22/25） and 32%（8/25）,respectively.Incidence of wheezing（16%） was significantly lower in the observation group than the control group（52%）.Conclusion：Since the relieving effect of erythromycin of asthma is gradually being discovered,macrolide antibiotics such as erythromycin should be used at an early stage in children with bronchiolitis.