In vitro activity of tigecycline against resistant micro-organisms isolated from burn patients |
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Authors: | Timurkaynak F Arslan H Azap O Kurt Senger S Serin Başaran O Karaman S Ozbalikci Haberal M |
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Affiliation: | 2. Department of Internal Medicine, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey |
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Abstract: | Infections in burn patients are usually caused by multidrug-resistant micro-organisms. Tigecycline, a derivative of glycylcyclines, is an effective antibiotic against the resistant strains. The aim of this study is to determine the in vitro activity of tigecycline against the multidrug-resistant bacteria isolated from burn patients. Fourty-seven bacteria isolated from 118 patients hospitalized in the burn unit during 2003-2006 were included in the study. Gram-negative bacteria that were resistant to at least six broad-spectrum antibiotics, methicillin-resistant staphylococci and ampicillin-resistant enterococci were studied. Minimal inhibitory concentration values of tigecycline against these bacteria were tested by E-test strips. Susceptibility breakpoints were determined according to the previous studies;
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